Class II transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC2 family of hexose and sugar alcohol transporters
Class II transporters

Class II transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Class II transporters transport D-fructose and appear to be insensitive to cytochalasin B. Class II transporters appear to be predominantly intracellularly located.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

GLUT5 (Glucose transporter 5 / SLC2A5) C Show summary »« Hide summary

Target Id

880

Nomenclature

Glucose transporter 5

Systematic nomenclature

SLC2A5

Common abbreviation

GLUT5

Previous and unofficial names

Small intestine glucose transporter | GLUT5 | fructose transporter | glucose transporter type 5, small intestine | solute carrier family 2, facilitated glucose transporter member 5 | solute carrier family 2, member 5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | solute carrier family 2 (facilitated glucose transporter)

Genes

SLC2A5 (Hs), Slc2a5 (Mm), Slc2a5 (Rn)

Ensembl ID

ENSG00000142583 (Hs), ENSMUSG00000028976 (Mm), ENSRNOG00000017693 (Rn)

UniProtKB AC

P22732 (Hs), Q9WV38 (Mm), P43427 (Rn)

Bioparadigms SLC Tables

SLC2A5 (Hs)

RESOLUTE

SLC2A5 (Hs)

Substrates

D-glucose (D-fructose > D-glucose) [1]

D-fructose (D-fructose > D-glucose) [1]

GLUT7 (Glucose transporter 7 / SLC2A7) C Show summary »« Hide summary

Target Id

881

Nomenclature

Glucose transporter 7

Systematic nomenclature

SLC2A7

Common abbreviation

GLUT7

Previous and unofficial names

GLUT7 | intestinal facilitative glucose transporter 7 | glucose transporter type 7 | solute carrier family 2, facilitated glucose transporter member 7 | solute carrier family 2 (facilitated glucose transporter), member 7 | solute carrier family 2 (facilitated glucose transporter)

Genes

SLC2A7 (Hs), Slc2a7 (Mm), Slc2a7 (Rn)

Ensembl ID

ENSG00000197241 (Hs), ENSMUSG00000062064 (Mm), ENSRNOG00000036951 (Rn)

UniProtKB AC

Q6PXP3 (Hs), P0C6A1 (Mm), A4ZYQ5 (Rn)

Bioparadigms SLC Tables

SLC2A7 (Hs)

RESOLUTE

SLC2A7 (Hs)

Substrates

D-glucose [3]

D-fructose [3]

GLUT9 (Glucose transporter 9 / SLC2A9) C Show summary »« Hide summary

Target Id

882

Nomenclature

Glucose transporter 9

Systematic nomenclature

SLC2A9

Common abbreviation

GLUT9

Previous and unofficial names

Genes

SLC2A9 (Hs), Slc2a9 (Mm), Slc2a9 (Rn)

Ensembl ID

ENSG00000109667 (Hs), ENSMUSG00000005107 (Mm), ENSRNOG00000005302 (Rn)

UniProtKB AC

Q9NRM0 (Hs)

Bioparadigms SLC Tables

SLC2A9 (Hs)

RESOLUTE

SLC2A9 (Hs)

Substrates

D-fructose [2]

uric acid [2]

GLUT11 (Glucose transporter 11 / SLC2A11) C Show summary »« Hide summary

Target Id

883

Nomenclature

Glucose transporter 11

Systematic nomenclature

SLC2A11

Common abbreviation

GLUT11

Previous and unofficial names

GLUT10 | solute carrier family 2 (facilitated glucose transporter), member 11

Genes

SLC2A11 (Hs)

Ensembl ID

ENSG00000133460 (Hs)

UniProtKB AC

Q9BYW1 (Hs)

Bioparadigms SLC Tables

SLC2A11 (Hs)

RESOLUTE

SLC2A11 (Hs)

Substrates

D-glucose [4]

D-fructose [7]

GLUT6 (Glucose transporter 6 / SLC2A6) C Show summary »« Hide summary

Target Id	884
Nomenclature	Glucose transporter 6
Systematic nomenclature	SLC2A6
Common abbreviation	GLUT6
Previous and unofficial names	GLUT9 \| solute carrier family 2, facilitated glucose transporter member 6 \| solute carrier family 2 (facilitated glucose transporter)
Genes	SLC2A6 (Hs), Slc2a6 (Mm), Slc2a6 (Rn)
Ensembl ID	ENSG00000160326 (Hs), ENSMUSG00000036067 (Mm), ENSRNOG00000005900 (Rn)
UniProtKB AC	Q9UGQ3 (Hs)
Bioparadigms SLC Tables	SLC2A6 (Hs)
RESOLUTE	SLC2A6 (Hs)

GLUT8 (Glucose transporter 8 / SLC2A8) C Show summary »« Hide summary

Target Id

885

Nomenclature

Glucose transporter 8

Systematic nomenclature

SLC2A8

Common abbreviation

GLUT8

Previous and unofficial names

GLUTX1 | glucose transporter type 8 | glucose transporter type X1 | solute carrier family 2, facilitated glucose transporter member 8 | solute carrier family 2 (facilitated glucose transporter), member 8 | solute carrier family 2, (facilitated glucose transporter) member 8 | solute carrier family 2, (facilitated glucose transporter), member 8 | solute carrier family 2

Genes

SLC2A8 (Hs), Slc2a8 (Mm), Slc2a8 (Rn)

Ensembl ID

ENSG00000136856 (Hs), ENSMUSG00000026791 (Mm), ENSRNOG00000022274 (Rn)

UniProtKB AC

Q9NY64 (Hs), Q9JIF3 (Mm), Q9JJZ1 (Rn)

Bioparadigms SLC Tables

SLC2A8 (Hs)

RESOLUTE

SLC2A8 (Hs)

Substrates

D-glucose [5]

GLUT10 (Glucose transporter 10 / SLC2A10) C Show summary »« Hide summary

Target Id

886

Nomenclature

Glucose transporter 10

Systematic nomenclature

SLC2A10

Common abbreviation

GLUT10

Previous and unofficial names

solute carrier family 2, facilitated glucose transporter member 10 | solute carrier family 2 (facilitated glucose transporter)

Genes

SLC2A10 (Hs), Slc2a10 (Mm), Slc2a10 (Rn)

Ensembl ID

ENSG00000197496 (Hs), ENSMUSG00000027661 (Mm), ENSRNOG00000025384 (Rn)

UniProtKB AC

O95528 (Hs), Q8VHD6 (Mm)

Bioparadigms SLC Tables

SLC2A10 (Hs)

RESOLUTE

SLC2A10 (Hs)

Substrates

D-glucose [6]

dehydroascorbic acid [6]

GLUT12 (Glucose transporter 12 / SLC2A12) C Show summary »« Hide summary

Target Id

887

Nomenclature

Glucose transporter 12

Systematic nomenclature

SLC2A12

Common abbreviation

GLUT12

Previous and unofficial names

GLUT8 | solute carrier family 2, facilitated glucose transporter member 12 | solute carrier family 2 (facilitated glucose transporter)

Genes

SLC2A12 (Hs), Slc2a12 (Mm), Slc2a12 (Rn)

Ensembl ID

ENSG00000146411 (Hs), ENSMUSG00000037490 (Mm), ENSRNOG00000011161 (Rn)

UniProtKB AC

Q8TD20 (Hs), Q8BFW9 (Mm)

Bioparadigms SLC Tables

SLC2A12 (Hs)

RESOLUTE

SLC2A12 (Hs)

Substrates

D-glucose [8]

References

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1. Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO. (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem, 267 (21): 14523-6. [PMID:1634504]

2. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P et al.. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med, 5 (10): e197. [PMID:18842065]

3. Cheeseman C. (2008) GLUT7: a new intestinal facilitated hexose transporter. Am J Physiol Endocrinol Metab, 295 (2): E238-41. [PMID:18477702]

4. Doege H, Bocianski A, Scheepers A, Axer H, Eckel J, Joost HG, Schürmann A. (2001) Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem J, 359 (Pt 2): 443-9. [PMID:11583593]

5. Ibberson M, Uldry M, Thorens B. (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem, 275 (7): 4607-12. [PMID:10671487]

6. Lee YC, Huang HY, Chang CJ, Cheng CH, Chen YT. (2010) Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. Hum Mol Genet, 19 (19): 3721-33. [PMID:20639396]

7. Manolescu AR, Augustin R, Moley K, Cheeseman C. (2007) A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol, 24 (5-6): 455-63. [PMID:17710649]

8. Rogers S, Chandler JD, Clarke AL, Petrou S, Best JD. (2003) Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes. Biochem Biophys Res Commun, 308 (3): 422-6. [PMID:12914765]

How to cite this family page

Database page citation:

Class II transporters. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=166.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.