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Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [2], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [1]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.
Table 1: Class A orphan GPCRs with putative endogenous ligands
| GPR3 | GPR4 | GPR6 | GPR12 | GPR15 | GPR17 | GPR20 |
| GPR22 | GPR26 | GPR31 | GPR34 | GPR35 | GPR37 | GPR39 |
| GPR50 | GPR63 | GPR65 | GPR68 | GPR75 | GPR84 | GPR87 |
| GPR88 | GPR132 | GPR149 | GPR161 | GPR183 | LGR4 | LGR5 |
| LGR6 | MAS1 | MRGPRD | MRGPRX1 | MRGPRX2 | P2RY10 | TAAR2 |
In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).
Subfamilies
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Families that contain targets of relevance to immunopharmacology are highlighted in blue |
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How to cite this family page
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.
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