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ABCC subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions. They are known to be involved in ion transport, toxin secretion, and signal transduction [1,5].

Transporters

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Targets of relevance to immunopharmacology are highlighted in blue

MRP1 (ABCC1) C Show summary » More detailed page go icon to follow link

MRP2, cMOAT (ABCC2) C Show summary » More detailed page go icon to follow link

MRP3 (ABCC3) C Show summary »

MRP4 (ABCC4) C Show summary » More detailed page go icon to follow link

MRP5 (ABCC5) C Show summary »

MRP6 (ABCC6) C Show summary »

SUR1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / ABCC8) C Show summary » More detailed page go icon to follow link

SUR2 (ABCC9) C Show summary » More detailed page go icon to follow link

MRP7 (ABCC10) Show summary »

MRP8 (ABCC11) C Show summary »

MRP9 (ABCC12) Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.