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Taste 2 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Taste 2 receptors or Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed in oral sensory cells and a variety of non-gustatory tissues. The ~25 human TAS2Rs share low amino acid sequence identities with other GPCR families and are classified as broadly tuned "generalist" receptors with numerous, chemically diverse bitter agonists, as narrowly tuned "specialist" receptors with very few activators, as intermediately tuned receptors with an average number of agonists, or receptors specialized to interact with chemically defined activators [32]. The number of functional bitter taste receptor genes varies among species and orthologues might not be functionally conserved. Due to their expression in various tissues, the signal transduction of TAS2Rs is complex. Some TAS2Rs interact with drugs such as analgesic, anti-inflammatory, and antibacterial compounds. The specialist database BitterDB contains additional information on bitter compounds and receptors [13].


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Targets of relevance to immunopharmacology are highlighted in blue

TAS2R1 C Show summary »

TAS2R3 C Show summary »

TAS2R4 C Show summary »

TAS2R5 C Show summary »

TAS2R7 C Show summary »

TAS2R8 C Show summary »

TAS2R9 C Show summary »

TAS2R10 C Show summary »

TAS2R13 C Show summary »

TAS2R14 C Show summary »

TAS2R16 C Show summary »

TAS2R19 C Show summary »

TAS2R20 C Show summary »

TAS2R30 C Show summary »

TAS2R31 C Show summary »

TAS2R38 C Show summary »

TAS2R39 C Show summary »

TAS2R40 C Show summary »

TAS2R41 C Show summary »

TAS2R42 C Show summary »

TAS2R43 C Show summary »

TAS2R45 C Show summary »

TAS2R46 C Show summary »

Target Id 679
Nomenclature TAS2R46
Previous and unofficial names T2R54 | taste receptor, type 2, member 46
Genes TAS2R46 (Hs)
Ensembl ID ENSG00000226761 (Hs)
UniProtKB AC P59540 (Hs)
BitterDB 46 (Hs)
Principal transduction -
lactucopicrin [27]
strychnine [8]
grosheimin [41]
absinthin [8]
bengalensol [29]
andrographolide [41]
amarogentin [41]
picrotoxinin [8]
denatonium [32]
colchicine [32]
L-Trp-Trp-Trp [25]
3β-hydroxydihydrocostunolide pIC50 5.3 [9]

TAS2R50 C Show summary »

TAS2R60 C Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.