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Taste 2 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Taste 2 receptors or Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed in oral sensory cells and a variety of non-gustatory tissues. The ~25 human TAS2Rs share low amino acid sequence identities with other GPCR families and are classified as broadly tuned "generalist" receptors with numerous, chemically diverse bitter agonists, as narrowly tuned "specialist" receptors with very few activators, as intermediately tuned receptors with an average number of agonists, or receptors specialized to interact with chemically defined activators [31]. The number of functional bitter taste receptor genes varies among species and orthologues might not be functionally conserved. Due to their expression in various tissues, the signal transduction of TAS2Rs is complex. Some TAS2Rs interact with drugs such as analgesic, anti-inflammatory, and antibacterial compounds. The specialist database BitterDB contains additional information on bitter compounds and receptors [13].


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Targets of relevance to immunopharmacology are highlighted in blue

TAS2R1 C Show summary »

TAS2R3 C Show summary »

TAS2R4 C Show summary »

TAS2R5 C Show summary »

TAS2R7 C Show summary »

TAS2R8 C Show summary »

TAS2R9 C Show summary »

TAS2R10 C Show summary »

TAS2R13 C Show summary »

TAS2R14 C Show summary »

Target Id 668
Nomenclature TAS2R14
Previous and unofficial names T2R14 | TRB1 | taste receptor, type 2, member 14
Genes TAS2R14 (Hs)
Ensembl ID ENSG00000212127 (Hs)
UniProtKB AC Q9NYV8 (Hs)
BitterDB 14 (Hs)
Principal transduction -
flufenamic acid [14]
aristolochic acid [34]
nobiletin [4]
luteolin [38]
santonin [34]
datiscetin [38]
parthenolide [34]
(-)-α-thujone [3]
picrotoxinin [3]
N-octanoyl-L-homoserine lactone [22]
phloretin [38]
resveratrol [38]
tributyrin [29]
eriodictyol chalcone [38]
(±)-Equol [39]
silibinin [38]
(+/-)-Eriodictyol [38]
genistein [34]
homoeriodictyol [38]
coumestrol [39]
vanillin [32]
lupulone [20]
quinine [31]
L-Trp-Trp-Trp [24]

TAS2R16 C Show summary »

TAS2R19 C Show summary »

TAS2R20 C Show summary »

TAS2R30 C Show summary »

TAS2R31 C Show summary »

TAS2R38 C Show summary »

TAS2R39 C Show summary »

TAS2R40 C Show summary »

TAS2R41 C Show summary »

TAS2R42 C Show summary »

TAS2R43 C Show summary »

TAS2R45 C Show summary »

TAS2R46 C Show summary »

TAS2R50 C Show summary »

TAS2R60 C Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.