Other 7TM proteins | G protein-coupled receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Other 7TM proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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These proteins are predicted to have 7TM domains, but functional studies have yet to confirm them as G protein-coupled receptors.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

GPR107 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	651
Nomenclature	GPR107
Previous and unofficial names	LUSTR1 \| GCDRP \| Lung seven transmembrane receptor 1
Genes	GPR107 (Hs), Gpr107 (Mm), Gpr107 (Rn)
Ensembl ID	ENSG00000148358 (Hs), ENSMUSG00000000194 (Mm), ENSRNOG00000023589 (Rn)
UniProtKB AC	Q5VW38 (Hs), Q8BUV8 (Mm), D3ZWZ9 (Rn)
Principal transduction	-
Comment	GPR107 is a member of the LUSTR family of proteins found in both plants and animals, having similar topology to G protein-coupled receptors [2]

GPR137 C Show summary »« Hide summary More detailed page go icon to follow link

TPRA1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	655
Nomenclature	TPRA1
Previous and unofficial names	GPR175 \| TMEM227 \| TPRA40 \| G protein-coupled receptor 175 \| transmembrane protein 227 \| transmembrane protein, adipocyte asscociated 1 \| transmembrane protein
Genes	TPRA1 (Hs), Tpra1 (Mm), Tpra1 (Rn)
Ensembl ID	ENSG00000163870 (Hs), ENSMUSG00000002871 (Mm), ENSRNOG00000016665 (Rn)
UniProtKB AC	Q86W33 (Hs), Q99MU1 (Mm), Q791F6 (Rn)
Principal transduction	-
Comment	TPRA1 shows no homology to known G protein-coupled receptors.

GPR143 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

203

Nomenclature

GPR143

Previous and unofficial names

MOA1 | ocular albinism 1 (Nettleship-Falls) | NYS6 | Ocular albinism type 1 protein

Genes

GPR143 (Hs), Gpr143 (Mm), Gpr143 (Rn)

Ensembl ID

ENSG00000101850 (Hs), ENSMUSG00000025333 (Mm), ENSRNOG00000003543 (Rn)

UniProtKB AC

P51810 (Hs), P70259 (Mm)

Principal transduction

Endogenous agonists

levodopa [3]

Comment

Loss-of-function mutations underlie ocular albinism type 1 [1].

GPR157 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	205
Nomenclature	GPR157
Genes	GPR157 (Hs), Gpr157 (Mm), Gpr157 (Rn)
Ensembl ID	ENSG00000180758 (Hs), ENSMUSG00000047875 (Mm), ENSRNOG00000017528 (Rn)
UniProtKB AC	Q5UAW9 (Hs), Q8C206 (Mm), Q5FVG1 (Rn)
Principal transduction	-
Comment	GPR157 has ambiguous sequence similarities to several different GPCR families (class A, class B and the slime mould cyclic AMP receptor). Because of its distant relationship to other GPCRs, it cannot be readily classified.

References

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1. Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A. (1995) Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat Genet, 10 (1): 13-9. [PMID:7647783]

2. Edgar AJ. (2007) Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. DNA Seq, 18 (3): 235-41. [PMID:17454009]

3. Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS. (2008) L-DOPA is an endogenous ligand for OA1. PLoS Biol, 6 (9): e236. [PMID:18828673]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Tom I. Bonner. Other 7TM proteins. Accessed on 24/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=113.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.