COMMD proteins

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The COMMD family consists of 10 proteins that share the structurally conserved carboxy-terminal motif, the COMM domain [1-2]. They are generally ubiquitously expressed, but exhibit distinct and non-redundant roles in a range of physiological processes. We include the members of the family for which clinical or therapeutic potential has been described.

Targets

Targets of relevance to immunopharmacology are highlighted in blue

copper metabolism domain containing 1 Show summary »« Hide summary

Target Id

3311

Nomenclature

copper metabolism domain containing 1

Previous and unofficial names

copper metabolism gene MURR1 | copper metabolism (Murr1) domain containing 1 | MURR1

Genes

COMMD1 (Hs), Commd1 (Mm), Commd1 (Rn)

Ensembl ID

ENSG00000173163 (Hs), ENSMUSG00000051355 (Mm), ENSRNOG00000009281 (Rn)

UniProtKB AC

Q8N668 (Hs), Q3V012 (Mm)

Ligands

CIGB-552 (Binding) [4]

Comment

COMMD1 is a multi-function protein that is involved in a range of biological processes, including copper homeostasis, regulation of protein localisation, regulation of NF-κB signaling, and it is proposed to be a component of the Cul2-RING ubiquitin ligase complex. A peptide that binds directly to COMMD1 (CIGB-552) has reported anti-tumour activity [4-5], and is also proposed to synergise with cystic fibrosis triple therapy Kaftrio (elexacaftor/tezacaftor/ivacaftor) to futher improve chloride transport via the cystic fibrosis CFTR-F508del protein variant. CIGB-552 is suggested to disrupt COMMD1-associated degradation of the misfolded mutated CFTR [3,6] and to enhance its localisation to the plasma membrane.

References

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1. Bartuzi P, Hofker MH, van de Sluis B. (2013) Tuning NF-κB activity: a touch of COMMD proteins. Biochim Biophys Acta, 1832 (12): 2315-21. [PMID:24080195]

2. Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS. (2005) COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem, 280 (23): 22222-32. [PMID:15799966]

3. Drévillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelièvre A, Aissat A, Tarze A, Goossens M, Fanen P. (2011) COMMD1-mediated ubiquitination regulates CFTR trafficking. PLoS One, 6 (3): e18334. [PMID:21483833]

4. Fernández Massó JR, Oliva Argüelles B, Tejeda Y, Astrada S, Garay H, Reyes O, Delgado-Roche L, Bollati-Fogolín M, Vallespí MG. (2013) The Antitumor Peptide CIGB-552 Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells. J Amino Acids, 2013: 251398. [PMID:23401744]

5. Gomez Rodriguez Y, Oliva Arguelles B, Riera-Romo M, Fernandez-De-Cossio J, Garay HE, Fernandez Masso J, Guerra Vallespi M. (2022) Synergic effect of anticancer peptide CIGB-552 and Cisplatin in lung cancer models. Mol Biol Rep, 49 (4): 3197-3212. [PMID:35094208]

6. Tanguy G, Drévillon L, Arous N, Hasnain A, Hinzpeter A, Fritsch J, Goossens M, Fanen P. (2008) CSN5 binds to misfolded CFTR and promotes its degradation. Biochim Biophys Acta, 1783 (6): 1189-99. [PMID:18267124]

How to cite this family page

Database page citation:

COMMD proteins. Accessed on 20/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1109.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.