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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The WIZ transcription factor is involved in regulating trancriptional activity via modulating interactions with DNA-binding transcription factors and transcription corepressors. It is also a component of the G9A (EHMT2)/GLP (EHMT1) H3K9 methyltransferase complex. WIZ participates in repression of fetal hemoglobin (HbF) expression. Targeted degradation of WIZ protein is being explored as a mechanism to reactivate HbF expression as a therapy for Sickle cell disease [1].
WIZ zinc finger Show summary » |
Database page citation:
Zinc finger TFs. Accessed on 02/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1102.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.