Top ▲

Autophagy receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Autophagy receptors are important for protein homeostasis, by regulating the clearance of protein aggregates, pathogens and the turnover of a wide range of cargo proteins, via the autophagosome-lysosome pathway, by ubiquitin-dependent and -independent mechanisms [3]. Their activity is modulated by protein modifications such as phosphorylation and ubiquitination. Some autophagy receptors have been associated with neurodegenerative diseases [2,10].

Targets

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

sequestosome 1 Show summary »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Autophagy receptors. Accessed on 23/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1073.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.