Complement system regulators

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Complement system regulators

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

Targets of relevance to immunopharmacology are highlighted in blue

clusterin Show summary »« Hide summary

Target Id

3195

Nomenclature

clusterin

Previous and unofficial names

APOJ | apolipoprotein J | complement lysis inhibitor, SP-40,40 | sulfated glycoprotein 2; SGP-2

Genes

CLU (Hs), Clu (Mm), Clu (Rn)

Ensembl ID

ENSG00000120885 (Hs), ENSMUSG00000022037 (Mm), ENSRNOG00000016460 (Rn)

UniProtKB AC

P10909 (Hs), Q06890 (Mm), P05371 (Rn)

Antibodies

sotevtamab (Binding) pK_d 8.4 [1]

Comment

Clusterin inhibits complement-mediated cytolysis, by preventing binding of C5b-C7 complexes to the membrane of the target cells. Anti-clusterin antibodies are in development as immunomodulators with antineoplastic potential.

References

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How to cite this family page

Database page citation:

Complement system regulators. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1069.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.