Transporters (<i>Plasmodium</i> spp.) | Other protein targets | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Transporters (Plasmodium spp.)

Overview

To survive and replicate during the intraerythrocytic lifecycle stages, the malaria parasite uses a range of transport processes to take up nutrients, export waste products, and maintain tight regulation over its own internal ionic environment [1]. Plasmodium membrane transport proteins are candidate targets for antimalarial drug discovery but have also been shown to play a role in the development of drug resistance.

Targets

Targets of relevance to immunopharmacology are highlighted in blue

PfATP4 (Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2971
Nomenclature	Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase
Common abbreviation	PfATP4
Previous and unofficial names	ATP4 \| Pf3D7_12_v3:527,829..533,965(-) \| P-type ATPase4 \| Plasmodium falciparum ATPase4 \| PFL0590c
Genes	ATP4 (Pf3D7)
UniProtKB AC	A0A143ZZK9 (Pf3D7)
PlasmoDB	PF3D7_1211900 (Pf3D7)

Plasmodium falciparum V-type proton ATPase subunit D C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3078
Nomenclature	Plasmodium falciparum V-type proton ATPase subunit D
Previous and unofficial names	PF3D7_1341900 \| Pf3D7_13_v3:1,649,035..1,651,981(-) \| Plasmodium falciparum V-type H+ ATPase \| PF13_0227
Genes	PF3D7_1341900 (Pf3D7)
UniProtKB AC	Q8IDS0 (Pf3D7)
PlasmoDB	PF3D7_1341900 (Pf3D7)

PfCARL (Plasmodium falciparum cyclic amine resistance locus protein) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3074
Nomenclature	Plasmodium falciparum cyclic amine resistance locus protein
Common abbreviation	PfCARL
Previous and unofficial names	CARL \| Pf3D7_03_v3:921,776..928,618(+) \| PFC0970w
Genes	CARL (Pf3D7)
UniProtKB AC	C0H483 (Pf3D7)
PlasmoDB	PF3D7_0321900 (Pf3D7)

PfHT1 (Plasmodium falciparum hexose transporter) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3069
Nomenclature	Plasmodium falciparum hexose transporter
Common abbreviation	PfHT1
Previous and unofficial names	HT1 \| Pf3D7_02_v3:204,784..207,425(-) \| hexose transporter 1 \| HT \| PF02_0044 \| PFB0210c
Genes	HT1 (Pf3D7)
UniProtKB AC	Q7KWJ5 (Pf3D7)
PlasmoDB	PF3D7_0204700 (Pf3D7)

PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3107
Nomenclature	Plasmodium falciparum Niemann-Pick type C1-related protein
Common abbreviation	PfNCR1
Previous and unofficial names	NCR1 \| Pf3D7_01_v3:303,437..311,928(-) \| PFA0375c
Genes	NCR1 (Pf3D7)
UniProtKB AC	Q8I266 (Pf3D7)
PlasmoDB	PF3D7_0107500 (Pf3D7)

References

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How to cite this family page

Database page citation:

Transporters (Plasmodium spp.). Accessed on 15/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1064.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.