Overview
To survive and replicate during the intraerythrocytic lifecycle stages, the malaria parasite uses a range of transport processes to take up nutrients, export waste products, and maintain tight regulation over its own internal ionic environment [1]. Plasmodium membrane transport proteins are candidate targets for antimalarial drug discovery but have also been shown to play a role in the development of drug resistance.
Targets
Targets of relevance to immunopharmacology are highlighted in blue
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PfATP4 (Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase) C
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Plasmodium falciparum V-type proton ATPase subunit D C
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PfCARL (Plasmodium falciparum cyclic amine resistance locus protein) C
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PfHT1 (Plasmodium falciparum hexose transporter) C
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PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein) C
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How to cite this family page
Database page citation:
Transporters (Plasmodium spp.). Accessed on 29/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1064.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.
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