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During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.
PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C
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PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C
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Database page citation:
Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 02/10/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1060.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.