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Nucleoside synthesis and metabolism (Plasmodium spp.)

Overview

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During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.

Targets

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Targets of relevance to immunopharmacology are highlighted in blue

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C Show summary » More detailed page go icon to follow link

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 28/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1060.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.