Adiponectin receptors (provisional nomenclature, ENSFM00500000270960) respond to the 30 kDa complement-related protein hormone adiponectin (also known as ADIPOQ: adipocyte, C1q and collagen domain-containing protein; ACRP30, adipose most abundant gene transcript 1; apM-1; gelatin-binding protein: Q15848) originally cloned from adipocytes [2]. Although sequence data suggest 7TM domains, immunological evidence indicates that, contrary to typical 7TM topology, the carboxyl terminus is extracellular, while the amino terminus is intracellular [4]. Signalling through these receptors appears to avoid G proteins; modelling based on the crystal structures of the adiponectin receptors suggested ceramidase acivity, which would make these the first in a new family of catalytic receptors [3].

T-Cadherin (CDH13, P55290) has also been suggested to be a receptor for (hexameric) adiponectin [1].

* Key recommended reading is highlighted with an asterisk

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Maynadier M, Basile I, Gary-Bobo M. (2009) Adiponectin normalization: a clue to the anti-metabolic syndrome action of rimonabant. Drug Discov Today, 14 (3-4): 192-7. [PMID:18951999]

* Okada-Iwabu M, Iwabu M, Yamauchi T, Kadowaki T. (2018) Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity. Endocr J, 65 (10): 971-977. [PMID:30282888]

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* Ruan H, Dong LQ. (2016) Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol, 8 (2): 101-9. [PMID:26993044]

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* Wang Y, Ma XL, Lau WB. (2017) Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification. Trends Endocrinol Metab, 28 (7): 519-530. [PMID:28473178]

* Zhao L, Fu Z, Liu Z. (2014) Adiponectin and insulin cross talk: the microvascular connection. Trends Cardiovasc Med, 24 (8): 319-24. [PMID:25220977]

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1. Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. (2004) T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA, 101 (28): 10308-13. [PMID:15210937]

2. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun, 221 (2): 286-9. [PMID:8619847]

3. Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T et al.. (2015) Crystal structures of the human adiponectin receptors. Nature, 520 (7547): 312-6. [PMID:25855295]

4. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M et al.. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423 (6941): 762-9. [PMID:12802337]