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Histone deacetylases (HDACs) (Plasmodium spp.)

Overview

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The histone deacetylase (HDAC) family of enzymes are involved in the post-translational modification of histones by removal of acetyl groups from lysine residues. Removal of the acetyl groups facilitates tighter packing of chromatin (heterochromatin formation) leading to transcriptional repression. In humans, the 18 members of the HDAC family have been classified in to five subfamilies based on phylogenetic comparison with yeast homologues (see our HDACs Concise family page for more details).

A recent review and analysis of the P. falciparum genome confirmed and classified the five known HDACs for this species of the parasite and identified a novel putative HDAC [4]:
Class I contains PfHDAC1
Class II contains PfHDA1 and PfHDA2
Class III contains the sirtuin-like PfSir2A and PfSir2B
PfCHD1 is a novel unclassified HDAC

HDACs have been identified as attractive molecular targets in the search for novel mechanisms to treat cancer and several small molecule HDAC inhibitors are already approved for clinical use. HDAC inhibitors have also emerged as potential therapies in a number of other disesases including malaria [1-3].

Targets

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Targets of relevance to immunopharmacology are highlighted in blue

PfHDAC1 (Plasmodium falciparum histone deacetylase 1) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Histone deacetylases (HDACs) (Plasmodium spp.). Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1059.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.