Non-mevalonate pathway enzymes

Overview

The non-mevalonate (MEP) pathway of isoprenoid precursor biosynthesis is utilized by bacteria, plants and apicomplexan protozoa but is not present in mammals (complete pathway for P. falciparum is available at www.wikipathways.org). Enzymes of this pathway represent promising therapeutic targets for antimalarial drug development because the pathway is present in the Plasmodium parasite but not in the human host [1].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2980
Nomenclature	Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Common abbreviation	PfDXR
Previous and unofficial names	DOXR \| IspC \| DOXP reductoisomerase \| DXP reductoisomerase
Genes	DXR (Pf3D7)
UniProtKB AC	Q8IKG4 (Pf3D7)
PlasmoDB	PF3D7_1467300 (Pf3D7)

PfIspD (Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3064
Nomenclature	Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Common abbreviation	PfIspD
Genes	IspD (Pf3D7)
UniProtKB AC	Q8I273 (Pf3D7)
PlasmoDB	PF3D7_0106900 (Pf3D7)

References

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Database page citation:

Non-mevalonate pathway enzymes. Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1055.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.