Kinases (<i>Plasmodium</i> spp.) | Other protein targets | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Kinases (Plasmodium spp.)

Overview

Kinases are a large family of enzymes responsible for the control of signal transduction pathways that regulate essential cellular processes in eukaryotic cells. The Plasmodium kinome is highly conserved across the genus but encodes a much smaller number of genes than that of the human kinome (see our Kinases Concise family page for more details of the latter) [1]. Both protein and lipid kinases are essential in signaling pathways during multiple stages of the parasite lifecycle and have emerged as attractive targets for antimalarial drug discovery [2-3].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

PfCLK3 (Plasmodium falciparum cyclin-dependent-like kinase CLK3) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3105
Nomenclature	Plasmodium falciparum cyclin-dependent-like kinase CLK3
Common abbreviation	PfCLK3
Previous and unofficial names	CLK3 \| Pf3D7_11_v3:553,917..559,114(+) \| PF11_0156
Genes	CLK3 (Pf3D7)
UniProtKB AC	Q8IIL5 (Pf3D7)
PlasmoDB	PF3D7_1114700 (Pf3D7)

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3013
Nomenclature	Plasmodium falciparum cGMP-dependent protein kinase
Common abbreviation	PfPKG
Previous and unofficial names	PKG \| Pf3D7_14_v3:1,490,321..1,494,453(-) \| PF14_0346
Genes	PKG (Pf3D7)
UniProtKB AC	Q8I719 (Pf3D7)
PlasmoDB	PF3D7_1436600 (Pf3D7)

PfPI3K (Plasmodium falciparum phosphatidylinositol 3-kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3073
Nomenclature	Plasmodium falciparum phosphatidylinositol 3-kinase
Common abbreviation	PfPI3K
Previous and unofficial names	PI3K \| Pf3D7_05_v3:628,784..635,412(+) \| VPS34 \| PFE0765w
Genes	PI3K (Pf3D7)
UniProtKB AC	Q8I3V5 (Pf3D7)
PlasmoDB	PF3D7_0515300 (Pf3D7)

PfPI4Kβ (Plasmodium falciparum phosphatidylinositol 4-kinase beta) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2972
Nomenclature	Plasmodium falciparum phosphatidylinositol 4-kinase beta
Common abbreviation	PfPI4Kβ
Previous and unofficial names	PI4KB \| Pf3D7_05_v3:409,403..415,758(+) \| phosphatidylinositol 4-kinase \| phosphatidylinositol 4-kinase type III beta \| PI4K \| PI4KIIIβ \| PI4KIIIbeta \| PFE0485w
Genes	PI4KB (Pf3D7)
UniProtKB AC	Q8I406 (Pf3D7)
PlasmoDB	PF3D7_0509800 (Pf3D7)

References

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1. Adderley J, Doerig C. (2022) Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens. BMC Genomics, 23 (1): 237. [PMID:35346035]

2. Arendse LB, Wyllie S, Chibale K, Gilbert IH. (2021) Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities. ACS Infect Dis, 7 (3): 518-534. [PMID:33590753]

3. Cabrera DG, Horatscheck A, Wilson CR, Basarab G, Eyermann CJ, Chibale K. (2018) Plasmodial Kinase Inhibitors: License to Cure?. J Med Chem, 61 (18): 8061-8077. [PMID:29771541]

How to cite this family page

Database page citation:

Kinases (Plasmodium spp.). Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1054.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.