Aminoacyl-tRNA synthetases

Overview

The aminoacyl-tRNA synthetases (aaRSs) are emerging targets for antimalarial agents [1]. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes.

Targets

Targets of relevance to immunopharmacology are highlighted in blue

Pfapi-IRS (Plasmodium falciparum isoleucine--tRNA ligase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3168
Nomenclature	Plasmodium falciparum isoleucine--tRNA ligase
Common abbreviation	Pfapi-IRS
Previous and unofficial names	Plasmodium falciparum isoleucyl-tRNA synthetase
Genes	api-IRS (Pf3D7)
UniProtKB AC	Q8I5G6 (Pf3D7)
PlasmoDB	PF3D7_1225100 (Pf3D7)

PfKRS1 (Plasmodium falciparum lysine--tRNA ligase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3059
Nomenclature	Plasmodium falciparum lysine--tRNA ligase
Common abbreviation	PfKRS1
Previous and unofficial names	Plasmodium falciparum lysyl-tRNA synthetase
Genes	KRS1 (Pf3D7)
UniProtKB AC	Q8IDJ8 (Pf3D7)
PlasmoDB	PF3D7_1350100 (Pf3D7)

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Common abbreviation	PfcPheRS
Previous and unofficial names	Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit \| Pfal cPheRS
Genes	cPheRS (Pf3D7)
UniProtKB AC	Q8I246 (Pf3D7)
PlasmoDB	PF3D7_0109800 (Pf3D7)

PfPRS (Plasmodium falciparum proline--tRNA ligase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3056
Nomenclature	Plasmodium falciparum proline--tRNA ligase
Common abbreviation	PfPRS
Previous and unofficial names	Plasmodium falciparum prolyl-tRNA synthetase \| PfPRORS
Genes	PRS (Pf3D7)
UniProtKB AC	Q8I5R7 (Pf3D7)
PlasmoDB	PF3D7_1213800 (Pf3D7)

PfThrRS (Plasmodium falciparum threonine--tRNA ligase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3058
Nomenclature	Plasmodium falciparum threonine--tRNA ligase
Common abbreviation	PfThrRS
Previous and unofficial names	Plasmodium falciparum threoninyl-tRNA synthetase
Genes	ThrRS (Pf3D7)
UniProtKB AC	Q8IIA4 (Pf3D7)
PlasmoDB	PF3D7_1126000 (Pf3D7)

PfaTrpRS (Plasmodium falciparum tryptophan--tRNA ligase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3166
Nomenclature	Plasmodium falciparum tryptophan--tRNA ligase
Common abbreviation	PfaTrpRS
Previous and unofficial names	Plasmodium falciparum tryptophanyl-tRNA synthetase
Genes	aTrpRS (Pf3D7)
UniProtKB AC	A0A144A140 (Pf3D7)
PlasmoDB	PF3D7_1251700 (Pf3D7)

References

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How to cite this family page

Database page citation:

Aminoacyl-tRNA synthetases. Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.