Aminoacyl-tRNA synthetases

Overview

The aminoacyl-tRNA synthetases (aaRSs) are a large and diverse enzyme family with an essential role in the ATP-dependent aminoacylation of cognate tRNAs with their respective amino acids for use in protein synthesis [2]. The P. falciparum genome encodes 36 different aaRSs, which participate in both cytoplasmic and organellar protein synthesis and are emerging targets for antimalarial agents [1,3].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

PfaIRS (Plasmodium falciparum isoleucyl-tRNA synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3168
Nomenclature	Plasmodium falciparum isoleucyl-tRNA synthetase
Common abbreviation	PfaIRS
Previous and unofficial names	Pfapi-IRS \| PFL1210w \| Plasmodium falciparum isoleucine--tRNA ligase
Genes	api-IRS (Pf3D7)
UniProtKB AC	Q8I5G6 (Pf3D7)
PlasmoDB	PF3D7_1225100 (Pf3D7)

PfcKRS (Plasmodium falciparum lysyl-tRNA synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3059
Nomenclature	Plasmodium falciparum lysyl-tRNA synthetase
Common abbreviation	PfcKRS
Previous and unofficial names	PfKRS1 \| PfKRS \| PfLysRS \| PF13_0262 \| Plasmodium falciparum lysine--tRNA
Genes	KRS1 (Pf3D7)
UniProtKB AC	Q8IDJ8 (Pf3D7)
PlasmoDB	PF3D7_1350100 (Pf3D7)

PfcFRS (Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit
Common abbreviation	PfcFRS
Previous and unofficial names	PfcPheRS \| PFA0480w \| Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Genes	cPheRS (Pf3D7)
UniProtKB AC	Q8I246 (Pf3D7)
PlasmoDB	PF3D7_0109800 (Pf3D7)

PfcPRS (Plasmodium falciparum prolyl-tRNA synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3056
Nomenclature	Plasmodium falciparum prolyl-tRNA synthetase
Common abbreviation	PfcPRS
Previous and unofficial names	PfProRS \| PFL0670c \| Plasmodium falciparum proline--tRNA ligase
Genes	PRS (Pf3D7)
UniProtKB AC	Q8I5R7 (Pf3D7)
PlasmoDB	PF3D7_1213800 (Pf3D7)

PfTRS (Plasmodium falciparum threonyl-tRNA synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3058
Nomenclature	Plasmodium falciparum threonyl-tRNA synthetase
Common abbreviation	PfTRS
Previous and unofficial names	PfThrRS \| PF11_0270 \| Plasmodium falciparum threonine--tRNA ligase
Genes	ThrRS (Pf3D7)
UniProtKB AC	Q8IIA4 (Pf3D7)
PlasmoDB	PF3D7_1126000 (Pf3D7)

PfaWRS (Plasmodium falciparum tryptophanyl-tRNA synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3166
Nomenclature	Plasmodium falciparum tryptophanyl-tRNA synthetase
Common abbreviation	PfaWRS
Previous and unofficial names	PfaTrpRS \| TrpRSapi \| PFL2485c \| Plasmodium falciparum tryptophan--tRNA ligase
Genes	aTrpRS (Pf3D7)
UniProtKB AC	A0A144A140 (Pf3D7)
PlasmoDB	PF3D7_1251700 (Pf3D7)

References

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1. Bhatt TK, Kapil C, Khan S, Jairajpuri MA, Sharma V, Santoni D, Silvestrini F, Pizzi E, Sharma A. (2009) A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum. BMC Genomics, 10: 644. [PMID:20042123]

2. Ibba M, Soll D. (2000) Aminoacyl-tRNA synthesis. Annu Rev Biochem, 69: 617-50. [PMID:10966471]

3. Manickam Y, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A. (2018) Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. Drug Discov Today, 23 (6): 1233-1240. [PMID:29408369]

How to cite this family page

Database page citation:

Aminoacyl-tRNA synthetases. Accessed on 02/04/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.