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Cyclic GMP-AMP synthase

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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cGAS acts as a pattern recognition sensor for cytosolic DNA. Its synthetic product cGAMP activates STING, which induces the interferon response, and production of inflammatory cytokines.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

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References

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How to cite this family page

Database page citation:

Cyclic GMP-AMP synthase. Accessed on 13/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1049.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.