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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Tetraspanins are a superfamily conserved membrane proteins with four transmembrane spanning domains [2,6], with 33 tetraspanin genes identified in the human genome. They are considered to be modulators (or facilitators) of cellular signalling and play significant roles in multiple biological processes [4].


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Targets of relevance to immunopharmacology are highlighted in blue

CD37 (CD37 molecule) Show summary » More detailed page go icon to follow link

Further reading

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How to cite this family page

Database page citation:

Tetraspanins. Accessed on 04/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.