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Tetraspanins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Tetraspanins are a superfamily conserved membrane proteins with four transmembrane spanning domains [2,6], with 33 tetraspanin genes identified in the human genome. They are considered to be modulators (or facilitators) of cellular signalling and play significant roles in multiple biological processes [4].

Targets

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Targets of relevance to immunopharmacology are highlighted in blue

CD37 (CD37 molecule) Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Tetraspanins. Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1047.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.