Tetraspanins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Tetraspanins are a superfamily conserved membrane proteins with four transmembrane spanning domains [2,6], with 33 tetraspanin genes identified in the human genome. They are considered to be modulators (or facilitators) of cellular signalling and play significant roles in multiple biological processes [4].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

CD37 (CD37 molecule) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3010
Nomenclature	CD37 molecule
Common abbreviation	CD37
Previous and unofficial names	CD37 antigen \| tetraspanin 26 \| TSPAN26
Genes	CD37 (Hs), Cd37 (Mm), Cd37 (Rn)
Ensembl ID	ENSG00000104894 (Hs), ENSMUSG00000030798 (Mm), ENSRNOG00000020699 (Rn)
UniProtKB AC	P11049 (Hs), P31053 (Rn)
Comment	The CD37 protein has 4 hydrophobic transmembrane domains, and it belongs to the tetraspanin (TSPAN) protein family (HGNC family ID 768) [1,5]. It is expressed solely by cells of the immune system, and is involved in the regulation of immune responses [3], cell development, activation, growth and motility [1,5].

References

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1. Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E. (2009) Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J, 420 (2): 133-54. [PMID:19426143]

2. Hemler ME. (2005) Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol, 6 (10): 801-11. [PMID:16314869]

3. Levy S, Shoham T. (2005) The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol, 5 (2): 136-48. [PMID:15688041]

4. Maecker HT, Todd SC, Levy S. (1997) The tetraspanin superfamily: molecular facilitators. FASEB J, 11 (6): 428-42. [PMID:9194523]

5. van Deventer SJ, Dunlock VE, van Spriel AB. (2017) Molecular interactions shaping the tetraspanin web. Biochem Soc Trans, 45 (3): 741-750. [PMID:28620035]

6. Wright MD, Tomlinson MG. (1994) The ins and outs of the transmembrane 4 superfamily. Immunol Today, 15 (12): 588-94. [PMID:7531445]

How to cite this family page

Database page citation:

Tetraspanins. Accessed on 10/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1047.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.