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Membrane bound O-acyltransferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The membrane bound O-acyltransferase (MBOAT) proteins form an evolutionarily conserved family of acyltransferase enzymes [1-2]. In humans there are eight MBOAT genes. MBOATs catalyse the transfer of an acyl group from an acyl-coenzyme or accessory protein to their target substrates. Family members are involved in many biological processes, including neutral lipid biosynthesis, protein/peptide acylation and phospholipid re-modelling.


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Targets of relevance to immunopharmacology are highlighted in blue

porcupine O-acyltransferase Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

Membrane bound O-acyltransferases. Accessed on 25/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.