The membrane bound O-acyltransferase (MBOAT) proteins form an evolutionarily conserved family of acyltransferase enzymes [1-2]. In humans there are eight MBOAT genes. MBOATs catalyse the transfer of an acyl group from an acyl-coenzyme or accessory protein to their target substrates. Family members are involved in many biological processes, including neutral lipid biosynthesis, protein/peptide acylation and phospholipid re-modelling.

1. Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W. (2018) Crystal structure of a membrane-bound O-acyltransferase. Nature, 562 (7726): 286-290. [PMID:30283133]

2. Masumoto N, Lanyon-Hogg T, Rodgers UR, Konitsiotis AD, Magee AI, Tate EW. (2015) Membrane bound O-acyltransferases and their inhibitors. Biochem Soc Trans, 43 (2): 246-52. [PMID:25849925]