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SLC65 NPC-type cholesterol transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC65 family of intracellular cholesterol transporters are 13TM membrane proteins. NPC1/SLC65A1 is an intracellular cholesterol transporter, which together with NPC2 (Uniprot ID P61916), allows the accumulation into the cytosol of cholesterol acquired from low density lipoproteins.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

NPC intracellular cholesterol transporter 1 / SLC65A1 C Show summary »

NPC1 like intracellular cholesterol transporter 1 / SLC65A2 C Show summary » More detailed page

Further reading

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References

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How to cite this family page

Database page citation:

SLC65 NPC-type cholesterol transporters. Accessed on 22/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1017.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.