SLC63 Sphingosine-phosphate transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC63 Sphingosine-phosphate transporters

SLC63 Sphingosine-phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC63 family of transporters has roles inside the cell (SLC63A1/SPNS1) or on the cell surface (SLC63A2/SPNS2) in sphingolipid transport.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

sphingolipid transporter 1 (putative) / SLC63A1 C Show summary »« Hide summary

Target Id	3047
Nomenclature	sphingolipid transporter 1 (putative)
Systematic nomenclature	SLC63A1
Previous and unofficial names	hSpin1 \| SPIN1 \| spinster homolog 1 (Drosophila)
Genes	SPNS1 (Hs), Spns1 (Mm), Spns1 (Rn)
Ensembl ID	ENSG00000169682 (Hs), ENSMUSG00000030741 (Mm), ENSRNOG00000017621 (Rn)
UniProtKB AC	Q9H2V7 (Hs), Q8R0G7 (Mm), Q2YDU8 (Rn)
Comment	Expressed in mitochondria [4].

sphingolipid transporter 2 / SLC63A2 Show summary »« Hide summary

Target Id

3048

Nomenclature

sphingolipid transporter 2

Systematic nomenclature

SLC63A2

Genes

SPNS2 (Hs), Spns2 (Mm), Spns2 (Rn)

Ensembl ID

ENSG00000183018 (Hs), ENSMUSG00000040447 (Mm), ENSRNOG00000057040 (Rn)

UniProtKB AC

Q8IVW8 (Hs), Q91VM4 (Mm)

Substrates

Phosphorylated fingolimod (FTY720-P) [1]

Phosphorylated sphingolipids [3]

Sphingosine-1-phosphate (S1P), dihydrosphingosine-1-phosphate (DH-S1P), phyto-S1P, C17-S1P [1]

Comment

Expressed in lung and placenta, and is abundant in many other tissues [1].

sphingolipid transporter 3 (putative) / SLC63A3 Show summary »« Hide summary

Target Id	3049
Nomenclature	sphingolipid transporter 3 (putative)
Systematic nomenclature	SLC63A3
Previous and unofficial names	spinster homolog 3 (Drosophila)
Genes	SPNS3 (Hs), Spns3 (Mm), Spns3 (Rn)
Ensembl ID	ENSMUSG00000020798 (Mm), ENSRNOG00000015873 (Rn)
UniProtKB AC	Q6ZMD2 (Hs), Q9D232 (Mm)
Comment	Highly expressed in rat coronal brain sections of the olfactory bulb and frontal cortex; moderately expressed in other coronal sections and in thymus, kidney, and spleen (qRT-PCR detection of mRNA) [2]

References

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1. Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T. (2011) The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J. Biol. Chem., 286 (3): 1758-66. [PMID:21084291]

2. Jacobsson JA, Haitina T, Lindblom J, Fredriksson R. (2007) Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics, 90 (5): 595-609. [PMID:17714910]

3. Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N. (2009) The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science, 323 (5913): 524-7. [PMID:19074308]

4. Yanagisawa H, Miyashita T, Nakano Y, Yamamoto D. (2003) HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ., 10 (7): 798-807. [PMID:12815463]

How to cite this family page

Database page citation:

SLC63 Sphingosine-phosphate transporters. Accessed on 22/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1015.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.