SLC57 NiPA-like magnesium transporter family | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC57 NiPA-like magnesium transporter family

SLC57 NiPA-like magnesium transporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

NIPA magnesium transporter 1 / SLC57A1 C Show summary »« Hide summary

Target Id

3033

Nomenclature

NIPA magnesium transporter 1

Systematic nomenclature

SLC57A1

Previous and unofficial names

NIPA3 [2] | non imprinted in Prader-Willi/Angelman syndrome 1 | SPG6

Genes

NIPA1 (Hs), Nipa1 (Mm), Nipa1 (Rn)

Ensembl ID

ENSG00000170113 (Hs), ENSMUSG00000047037 (Mm), ENSRNOG00000042702 (Rn)

UniProtKB AC

Q7RTP0 (Hs), Q8BHK1 (Mm)

RESOLUTE

NIPA1 (Hs)

Substrates

Mg²⁺ [1]

Sr²⁺, Fe²⁺ and Co²⁺ to a lesser extent [2]

Comment

Human tissue expression: Constitutively expressed at low levels, with significant enrichment in the brain [3].
Mouse tissue expression: Widely expressed, including in the heart, kidney, liver, colon, less in the brain, and not in the small intestine [1].

NIPA magnesium transporter 2 / SLC57A2 C Show summary »« Hide summary

Target Id

3034

Nomenclature

NIPA magnesium transporter 2

Systematic nomenclature

SLC57A2

Previous and unofficial names

non imprinted in Prader-Willi/Angelman syndrome 2

Genes

NIPA2 (Hs), Nipa2 (Mm), Nipa2 (Rn)

Ensembl ID

ENSG00000140157 (Hs), ENSMUSG00000030452 (Mm), ENSRNOG00000012690 (Rn)

UniProtKB AC

Q8N8Q9 (Hs), Q9JJC8 (Mm)

RESOLUTE

NIPA2 (Hs)

Substrates

Mg²⁺ [2]

NIPA like domain containing 1 / SLC57A3 C Show summary »« Hide summary

NIPA like domain containing 2 / SLC57A4 Show summary »« Hide summary

NIPA like domain containing 3 / SLC57A5 C Show summary »« Hide summary

NIPA like domain containing 4 / SLC57A6 Show summary »« Hide summary

References

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1. Goytain A, Hines RM, El-Husseini A, Quamme GA. (2007) NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter. J Biol Chem, 282 (11): 8060-8. [PMID:17166836]

2. Goytain A, Hines RM, Quamme GA. (2008) Functional characterization of NIPA2, a selective Mg2+ transporter. Am J Physiol, Cell Physiol, 295 (4): C944-53. [PMID:18667602]

3. Rainier S, Chai JH, Tokarz D, Nicholls RD, Fink JK. (2003) NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am J Hum Genet, 73 (4): 967-71. [PMID:14508710]

How to cite this family page

Database page citation:

SLC57 NiPA-like magnesium transporter family. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1009.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC57 NiPA-like magnesium transporter family C

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

Further reading

References

How to cite this family page