SLC55 Mitochondrial cation/proton exchangers | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC55 Mitochondrial cation/proton exchangers

SLC55 Mitochondrial cation/proton exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

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leucine zipper and EF-hand containing transmembrane protein 1 / SLC55A1 C Show summary »« Hide summary

Target Id

3025

Nomenclature

leucine zipper and EF-hand containing transmembrane protein 1

Systematic nomenclature

SLC55A1

Previous and unofficial names

Mdm38 homolog

Genes

LETM1 (Hs), Letm1 (Mm), Letm1 (Rn)

Ensembl ID

ENSG00000168924 (Hs), ENSMUSG00000005299 (Mm), ENSRNOG00000016427 (Rn)

UniProtKB AC

O95202 (Hs), Q9Z2I0 (Mm), Q5XIN6 (Rn)

RESOLUTE

LETM1 (Hs)

Transport type

Exchanger / Ca²⁺:H⁺ [3,6]

Transport type

Exchanger / K⁺:H⁺ [1,4]

Substrates

Ca²⁺, K⁺, H⁺ [1,4-5,7]

Comment

SLC55A1 is ubiquitously expressed [2]. Arguments against SLC55A1's role as a Ca²⁺ transporter are outlined by Zotova et al. (2010) [7].

leucine zipper and EF-hand containing transmembrane protein 2 / SLC55A2 C Show summary »« Hide summary

LETM1 domain containing 1 / SLC55A3 C Show summary »« Hide summary

Comments

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References

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1. Dimmer KS, Navoni F, Casarin A, Trevisson E, Endele S, Winterpacht A, Salviati L, Scorrano L. (2008) LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability. Hum Mol Genet, 17 (2): 201-14. [PMID:17925330]

2. Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A. (1999) LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. Genomics, 60 (2): 218-25. [PMID:10486213]

3. Jiang D, Zhao L, Clapham DE. (2009) Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science, 326 (5949): 144-7. [PMID:19797662]

4. Nowikovsky K, Froschauer EM, Zsurka G, Samaj J, Reipert S, Kolisek M, Wiesenberger G, Schweyen RJ. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem, 279 (29): 30307-15. [PMID:15138253]

5. Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ. (2007) Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death Differ, 14 (9): 1647-56. [PMID:17541427]

6. Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X, Cong Y, Shen Y. (2016) Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca²⁺/H⁺ antiporter. Sci Rep, 6: 34174. [PMID:27669901]

7. Zotova L, Aleschko M, Sponder G, Baumgartner R, Reipert S, Prinz M, Schweyen RJ, Nowikovsky K. (2010) Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem, 285 (19): 14399-414. [PMID:20197279]

How to cite this family page

Database page citation:

SLC55 Mitochondrial cation/proton exchangers. Accessed on 24/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1007.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.