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Nuclear export proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Cancer cells are able inactivate the function of tumour suppressor proteins (TSPs) by overexpressing the nuclear export protein, XPO1, which results in TSP mislocalisation to the cytopasm. Pharmacological inhibition of XPO1 in cancer cells promotes nuclear retention of TSP cargo proteins such as p53, Foxo, and BRCA1, and this activity restores TSP function and leads to cycle arrest and enhanced cancer cell apoptosis. This approach is being expoited as a novel anti-cancer mechanism [1-2].


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Targets of relevance to immunopharmacology are highlighted in blue

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How to cite this family page

Database page citation:

Nuclear export proteins. Accessed on 23/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.