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Sialic acid binding Ig like lectins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SIGLECs are a family of type I transmembrane proteins that are predominantly expressed by hemopoietic cells and they play critical roles in immune cell signaling and discrimination of self and nonself. The SIGLECs act as checkpoints in immune responses in human diseases including cancer, asthma, allergy, neurodegeneration, and autoimmune diseases and are being investigated as therapeutic targets [3].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

SIGLEC2 (CD22) Show summary » More detailed page

SIGLEC3 (CD33) C Show summary » More detailed page

SIGLEC8 (sialic acid binding Ig like lectin 8) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Sialic acid binding Ig like lectins. Accessed on 03/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1000.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.