5A. Fushi tarazu F1-like receptors | Nuclear hormone receptors

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5A. Fushi tarazu F1-like receptors

5A. Fushi tarazu F1-like receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fushi tarazu F1-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1]) have yet to be officially paired with an endogenous ligand.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Steroidogenic factor 1 / NR5A1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	632
Nomenclature	Steroidogenic factor 1
Systematic nomenclature	NR5A1
Previous and unofficial names	ELP \| FTZ1 \| SF-1 \| adrenal 4-binding protein \| steroid hormone receptor Ad4BP \| FTZF1 \| fushi tarazu factor homolog 1 \| STF-1 \| nuclear receptor subfamily 5, group A, member 1 \| nuclear receptor subfamily 5
Genes	NR5A1 (Hs), Nr5a1 (Mm), Nr5a1 (Rn)
Ensembl ID	ENSG00000136931 (Hs), ENSMUSG00000026751 (Mm), ENSRNOG00000012682 (Rn)
UniProtKB AC	Q13285 (Hs), P33242 (Mm), P50569 (Rn)
Comment	Reported to be inhibited by AC45594 [2] and SID7969543 [3].

Liver receptor homolog-1 / NR5A2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	633
Nomenclature	Liver receptor homolog-1
Systematic nomenclature	NR5A2
Previous and unofficial names	B1F2 \| FTZ-F1 \| hB1F-2 \| α1-fetoprotein transcription factor \| B1-binding factor \| hepatocytic transcription factor \| LRH-1 \| FTF \| FTZ-F1 beta2 protein \| liver receptor homolog 1 \| FTZ-F1β \| nuclear receptor subfamily 5
Genes	NR5A2 (Hs), Nr5a2 (Mm), Nr5a2 (Rn)
Ensembl ID	ENSG00000116833 (Hs), ENSMUSG00000026398 (Mm), ENSRNOG00000000653 (Rn)
UniProtKB AC	O00482 (Hs), P45448 (Mm), Q9QWM1 (Rn)

References

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1. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

2. Del Tredici AL, Andersen CB, Currier EA, Ohrmund SR, Fairbain LC, Lund BW, Nash N, Olsson R, Piu F. (2008) Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes. Mol Pharmacol, 73 (3): 900-8. [PMID:18055761]

3. Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P. (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol, 73 (6): 1776-84. [PMID:18334597]

How to cite this family page

Database page citation:

5A. Fushi tarazu F1-like receptors. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=100.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors. Br J Pharmacol. 180 Suppl 2:S223-240.