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5-Hydroxytryptamine receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [65] and subsequently revised [59]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [14,159]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [125,150]).

Receptors

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Targets of relevance to immunopharmacology are highlighted in blue

5-HT1A receptor C Show summary » More detailed page go icon to follow link

5-HT1B receptor C Show summary » More detailed page go icon to follow link

5-HT1D receptor C Show summary » More detailed page go icon to follow link

5-ht1e receptor C Show summary » More detailed page go icon to follow link

5-HT1F receptor C Show summary » More detailed page go icon to follow link

5-HT2A receptor C Show summary » More detailed page go icon to follow link

5-HT2B receptor C Show summary » More detailed page go icon to follow link

5-HT2C receptor C Show summary » More detailed page go icon to follow link

5-HT4 receptor C Show summary » More detailed page go icon to follow link

5-HT5A receptor C Show summary » More detailed page go icon to follow link

5-ht5b receptor C Show summary » More detailed page go icon to follow link

5-HT6 receptor C Show summary » More detailed page go icon to follow link

5-HT7 receptor C Show summary » More detailed page go icon to follow link

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.