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Ischemia-reperfusion injury

Disease ID:513
Name:Ischemia-reperfusion injury
Associated with:1 target


C5a1 receptor
Role:  The role of C5aR has been well studied in ischaemia/reperfusion (IR) injury. C5aR has been demonstrated to play a proinflammatory role, contributing to pathology, in IR injury of the heart, kidney, liver, intestine, and brain.
References:  1-9


No ligand related data available for Ischemia-reperfusion injury


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1. Arumugam TV, Shiels IA, Strachan AJ, Abbenante G, Fairlie DP, Taylor SM. (2003) A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney Int, 63 (1): 134-42. [PMID:12472776]

2. Arumugam TV, Woodruff TM, Lathia JD, Selvaraj PK, Mattson MP, Taylor SM. (2009) Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience, 158 (3): 1074-89. [PMID:18691639]

3. Arumugam TV, Woodruff TM, Stocks SZ, Proctor LM, Pollitt S, Shiels IA, Reid RC, Fairlie DP, Taylor SM. (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J Hepatol, 40 (6): 934-41. [PMID:15158333]

4. de Vries B, Köhl J, Leclercq WK, Wolfs TG, van Bijnen AA, Heeringa P, Buurman WA. (2003) Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils. J Immunol, 170 (7): 3883-9. [PMID:12646657]

5. Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC. (2003) C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. Clin Immunol, 108 (3): 263-73. [PMID:14499250]

6. Lewis AG, Köhl G, Ma Q, Devarajan P, Köhl J. (2008) Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival. Clin Exp Immunol, 153 (1): 117-26. [PMID:18505432]

7. Van Beek J, Bernaudin M, Petit E, Gasque P, Nouvelot A, MacKenzie ET, Fontaine M. (2000) Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse. Exp Neurol, 161 (1): 373-82. [PMID:10683302]

8. Xu DZ, Zaets SB, Chen R, Lu Q, Rajan H, Yang X, Zhang J, Feketova E, Bogdan N, Deitch EA et al.. (2009) Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs. Shock, 31 (5): 493-9. [PMID:18791492]

9. Zhang H, Qin G, Liang G, Li J, Barrington RA, Liu DX. (2007) C5aR-mediated myocardial ischemia/reperfusion injury. Biochem Biophys Res Commun, 357 (2): 446-52. [PMID:17416341]