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Injury aggravation in neurotrauma

Disease ID:499
Name:Injury aggravation in neurotrauma
Associated with:1 target


C5a1 receptor
Role:  In a mouse model of neurotrauma, invoked by the application of a liquid nitrogen cooled probe to the skull, C5aR has been demonstrated to be a key factor in injury aggravation. The authors attribute the attenuation of injury in both mice treated with the C5aR antagonist, PMX53, and mice deficient in C5, to a reduced neutrophil infiltration of the brain tissue post-injury. By contrast, in a rat model of spinal cord contusion injury, C5aR inhibition with PMX53 worsended injury outcomes.
References:  1-2


No ligand related data available for Injury aggravation in neurotrauma


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1. Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ. (2010) Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain, 133 (Pt 2): 433-47. [PMID:20085927]

2. Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD, Sandor M, Fabry Z. (2004) Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol, 155 (1-2): 55-63. [PMID:15342196]