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Disease ID:1127
Associated with:3 targets
Database Links
OMIM: 607834


regulator of G-protein signaling 2
Comments:  Anxiety and panic disorder.
References:  1-5
regulator of G-protein signaling 6
Role:  RGS6 acts to promote anxiety and depression.
References:  6


No ligand related data available for Anxiety


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1. Hohoff C, Weber H, Richter J, Domschke K, Zwanzger PM, Ohrmann P, Bauer J, Suslow T, Kugel H, Baumann C et al.. (2015) RGS2 ggenetic variation: association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety. Am J Med Genet B Neuropsychiatr Genet, 168B (3): 211-22. [PMID:25740197]

2. Leygraf A, Hohoff C, Freitag C, Willis-Owen SA, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J et al.. (2006) Rgs 2 gene polymorphisms as modulators of anxiety in humans?. J Neural Transm, 113 (12): 1921-5. [PMID:16736243]

3. Mouri K, Hishimoto A, Fukutake M, Nishiguchi N, Shirakawa O, Maeda K. (2010) Association study of RGS2 gene polymorphisms with panic disorder in Japanese. Kobe J Med Sci, 55 (5): E116-21. [PMID:20847599]

4. Otowa T, Shimada T, Kawamura Y, Sugaya N, Yoshida E, Inoue K, Yasuda S, Liu X, Minato T, Tochigi M et al.. (2011) Association of RGS2 variants with panic disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet, 156B (4): 430-4. [PMID:21438143]

5. Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. (2008) Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry, 65 (3): 298-308. [PMID:18316676]

6. Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA. (2014) Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J, 28 (4): 1735-44. [PMID:24421401]