Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	697	19q13.41	SIGLEC10	sialic acid binding Ig like lectin 10
Mouse	1	688	7 B3	Siglecg	sialic acid binding Ig-like lectin G
Rat	1	372	1q22	Siglec10	sialic acid binding Ig-like lectin 10

Database Links
Alphafold	Q96LC7 (Hs), Q80ZE3 (Mm)
ChEMBL Target	CHEMBL4303061 (Hs)
Ensembl Gene	ENSG00000142512 (Hs), ENSMUSG00000030468 (Mm), ENSRNOG00000037339 (Rn)
Entrez Gene	89790 (Hs), 243958 (Mm), 292844 (Rn)
Human Protein Atlas	ENSG00000142512 (Hs)
KEGG Gene	hsa:89790 (Hs), mmu:243958 (Mm), rno:292844 (Rn)
OMIM	606091 (Hs)
Pharos	Q96LC7 (Hs)
RefSeq Nucleotide	NM_033130 (Hs), NM_172900 (Mm), NM_001106250 (Rn)
RefSeq Protein	NP_149121 (Hs), NP_766488 (Mm), NP_001099720 (Rn)
UniProtKB	Q96LC7 (Hs), Q80ZE3 (Mm)
Wikipedia	SIGLEC10 (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference MK-7110 Hs Agonist - - 3 ⤷ [3]

Immunopharmacology Comments

Siglec-10 is an inhibitory co-receptor that is expressed by cells of the innate immune system. Its interaction with CD24 reduces the T cell response to danger-associated molecular patterns (DAMPs) [2]. Use of a synthetic CD24 mimetic has been shown to reduce tissue damage-induced immune responses [1].