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T-cell surface glycoprotein CD3 zeta chain (CD247)

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 3142

Nomenclature: T-cell surface glycoprotein CD3 zeta chain (CD247)

Family: CD molecules

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 164 1q24.2 CD247 CD247 molecule
Mouse 1 164 1 73.14 cM Cd247 CD247 antigen
Rat 1 164 13q23 Cd247 Cd247 molecule
Database Links Click here for help
Alphafold P20963 (Hs), P24161 (Mm), Q4V7G0 (Rn)
Ensembl Gene ENSG00000198821 (Hs), ENSMUSG00000005763 (Mm), ENSRNOG00000003298 (Rn)
Entrez Gene 919 (Hs), 12503 (Mm), 25300 (Rn)
Human Protein Atlas ENSG00000198821 (Hs)
KEGG Gene hsa:919 (Hs), mmu:12503 (Mm), rno:25300 (Rn)
Pharos P20963 (Hs)
UniProtKB P20963 (Hs), P24161 (Mm), Q4V7G0 (Rn)
Wikipedia CD247 (Hs)
Immunopharmacology Comments
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002250 adaptive immune response NAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0038094 Fc-gamma receptor signaling pathway IDA
GO:0046629 gamma-delta T cell activation NAS
GO:0046631 alpha-beta T cell activation NAS
GO:0050852 T cell receptor signaling pathway IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0038094 Fc-gamma receptor signaling pathway IDA
GO:0050852 T cell receptor signaling pathway IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0002250 adaptive immune response NAS
GO:0046629 gamma-delta T cell activation NAS
GO:0046631 alpha-beta T cell activation NAS

How to cite this page

CD molecules: T-cell surface glycoprotein CD3 zeta chain (CD247). Last modified on 30/07/2020. Accessed on 20/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3142.