Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	699		CLK3	cyclin-dependent-like kinase CLK3

Previous and Unofficial Names

CLK3 | Pf3D7_11_v3:553,917..559,114(+) | PF11_0156

Database Links
Alphafold	Q8IIL5 (Pf3D7)
PlasmoDB	PF3D7_1114700 (Pf3D7)
UniProtKB	Q8IIL5 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference TCMDC-135051 PfDd2 Plasmodium falciparum Dd2 P. falciparum strain Dd2 (PfDd2) is a clone derived from PfW2, following continuous culture in mefloquine. PfW2 was cloned from the Indochina III/CDC isolate, originally derived from a Laotian patient who failed chloroquine therapy. PfDd2 can be obtained from the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be resistant to chloroquine, pyrimethamine and mefloquine. ✖ - - 6.9 pEC50 1 ⤷ pEC50 6.9 (EC50 1.13x10-7 M) [1] TCMDC-135051 Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ - - 6.5 pEC50 1 ⤷ pEC50 6.5 (EC50 3.2x10-7 M) [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont) TCMDC-135051 Pb Plasmodium berghei P. berghei (Pb) is a malaria parasite that infects mammals other than humans with the natural mammalian host being the thicket rat (G. surdaster) from Central Africa. Pb is used in rodent model studies of malaria. ✖ - - 6.4 pEC50 1 ⤷ pEC50 6.4 (EC50 4x10-7 M) [1] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)

Malaria Pharmacology Comments

P. falciparum cyclin-dependent-like kinase CLK3 (PfCLK3) has been validated as an antimalarial target acting at multiple parasite life stages [1]. PfCLK3 is one of four members of the cyclin-dependent like protein kinase family (PfCLK1-4) with a key role in pre-RNA splicing and processing.