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PVR related immunoglobulin domain containing

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 3080

Nomenclature: PVR related immunoglobulin domain containing

Abbreviated Name: PVRIG

Family: Other immune checkpoint proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 326 7q22.1 PVRIG PVR related immunoglobulin domain containing
Mouse - - 5 G2 Pvrig poliovirus receptor related immunoglobulin domain containing
Rat - - 12q11 Pvrig PVR related immunoglobulin domain containing
Previous and Unofficial Names Click here for help
CD112 receptor | nectin-2 receptor | poliovirus receptor related immunoglobulin domain containing | CD112R
Database Links Click here for help
Alphafold Q6DKI7 (Hs)
Ensembl Gene ENSG00000213413 (Hs), ENSMUSG00000109713 (Mm), ENSRNOG00000051906 (Rn)
Entrez Gene 79037 (Hs), 102640920 (Mm), 680923 (Rn)
Human Protein Atlas ENSG00000213413 (Hs)
KEGG Gene hsa:79037 (Hs), mmu:102640920 (Mm), rno:680923 (Rn)
OMIM 617012 (Hs)
Pharos Q6DKI7 (Hs)
RefSeq Nucleotide NM_024070 (Hs)
RefSeq Protein NP_076975 (Hs)
UniProtKB Q6DKI7 (Hs)
Wikipedia PVRIG (Hs)
Natural/Endogenous Ligands Click here for help
Comments: PVRIG has been shown to interact with nectin-2 (a.k.a. PVRL2: NECTIN2; Q92692) [1]. This interaction mediates a co-inhibitory signal that blocks T cell activation/proliferation [1,3].
Immunopharmacology Comments
PVRIG has been identified as a novel co-inhibitory immune checkpoint, that is exploited by some cancer cells to evade immune detection [1-2]. Disruption of the PVRIG/PVRL2 interaction by antagonistic anti-PVRIG antibodies reduces tumour growth in preclinical models [1]. An anti-human PVRIG monoclonal antibody called COM701 is being developed by Compugen for immuno-oncology potential in patients with advanced solid tumours- see Phase 1 clinical trial NCT03667716 which is evaluating COM701 as a monotherapy and in combination with the PD-1 checkpoint inhibitor nivolumab.
Cell Type Associations
Immuno Cell Type:  Natural killer cells
Cell Ontology Term:   natural killer cell (CL:0000623)
Comment:  PVRIG is constitutively expressed by human and murine NK cells.
References:  1
Immuno Cell Type:  T cells
Comment:  PVRIG is constitutively expressed by human and murine NKT cells.
References:  1
Immuno Process Associations
Immuno Process:  Cellular signalling
Immuno Process:  Immune regulation

References

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1. Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T et al.. (2019) Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res, 7 (2): 244-256. [PMID:30659055]

2. Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K et al.. (2019) PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunol Res, 7 (2): 257-268. [PMID:30659054]

3. Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. (2016) Identification of CD112R as a novel checkpoint for human T cells. J Exp Med, 213 (2): 167-76. [PMID:26755705]

How to cite this page

Other immune checkpoint proteins: PVR related immunoglobulin domain containing. Last modified on 18/03/2019. Accessed on 15/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3080.