PVR related immunoglobulin domain containing | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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PVR related immunoglobulin domain containing

  Target has curated data in GtoImmuPdb

Target id: 3080

Nomenclature: PVR related immunoglobulin domain containing

Abbreviated Name: PVRIG

Family: Other immune checkpoint proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 326 7q22.1 PVRIG PVR related immunoglobulin domain containing
Mouse - - 5 G2 Pvrig poliovirus receptor related immunoglobulin domain containing
Rat - - 12q11 Pvrig PVR related immunoglobulin domain containing
Previous and Unofficial Names
CD112 receptor | nectin-2 receptor | poliovirus receptor related immunoglobulin domain containing | CD112R
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
Comments: PVRIG has been shown to interact with nectin-2 (a.k.a. PVRL2: NECTIN2; Q92692) [1]. This interaction mediates a co-inhibitory signal that blocks T cell activation/proliferation [1,3].
Immunopharmacology Comments
PVRIG has been identified as a novel co-inhibitory immune checkpoint, that is exploited by some cancer cells to evade immune detection [1-2]. Disruption of the PVRIG/PVRL2 interaction by antagonistic anti-PVRIG antibodies reduces tumour growth in preclinical models [1]. An anti-human PVRIG monoclonal antibody called COM701 is being developed by Compugen for immuno-oncology potential in patients with advanced solid tumours- see Phase 1 clinical trial NCT03667716 which is evaluating COM701 as a monotherapy and in combination with the PD-1 checkpoint inhibitor nivolumab.
Cell Type Associations
Immuno Cell Type:  Natural killer cells
Cell Ontology Term:   natural killer cell (CL:0000623)
Comment:  PVRIG is constitutively expressed by human and murine NK cells.
References:  1
Immuno Cell Type:  T cells
Comment:  PVRIG is constitutively expressed by human and murine NKT cells.
References:  1
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0050860 negative regulation of T cell receptor signaling pathway IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050860 negative regulation of T cell receptor signaling pathway IMP

References

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1. Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T et al.. (2019) Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res, 7 (2): 244-256. [PMID:30659055]

2. Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K et al.. (2019) PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunol Res, 7 (2): 257-268. [PMID:30659054]

3. Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. (2016) Identification of CD112R as a novel checkpoint for human T cells. J. Exp. Med., 213 (2): 167-76. [PMID:26755705]

How to cite this page

Other immune checkpoint proteins: PVR related immunoglobulin domain containing. Last modified on 18/03/2019. Accessed on 26/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3080.