Top ▲

Fc fragment of IgA receptor

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2991

Nomenclature: Fc fragment of IgA receptor

Abbreviated Name: FcαRI

Systematic Nomenclature: CD89

Family: CD molecules, Immunoglobulin like domain containing proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 287 19q13.42 FCAR Fc fragment of IgA receptor 2,6
Rat 1 280 1q12 Fcar Fc fragment of IgA receptor
Gene and Protein Information Comments
Alternative transcripts from the human gene produce shorter protein isoforms: isoforms b-h which vary in length from 178-275 aa. There is no mouse FCAR homolog.
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
BsAb (CD89-CD20) Peptide Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 8.5 pKd 3
pKd 8.5 (Kd 3.25x10-9 M) [3]
Description: FACS analysis of antibody binding to CD89-positive PMN cells.
Immunopharmacology Comments
FcαRI is the cognate receptor for immunoglobulin A (IgA). In humans, IgA is predominantly expressed in the intestine, where it is important for maintaining mucosal homeostasis. IgA serves as a first-line defence to protect the gut epithelium from pathogens and enteric toxins [4,7], facilitates immune exclusion (clearance of mucous-entrapped antigens and pathogens by peristaltic and mucociliary activities), and is also crucial for sensing commensal bacteria [5]. FcαRI actions include ADCC, phagocytosis, induction of respiratory bursts, and inflammatory mediator/cytokine release [8]. Studies by Hansen et al. (2018) have shown that CD103+SIRPα+ DCs can be transformed in to pro-inflammatory cells via a process involving FcαRI co-stimulation-induced glycolytic reprogramming. This work shows how IgA-immune complexes in the human intestine can convert a tolerogenic milieu to a pro-inflammatory one, following exposure to environmental agents [1].

An anti-FcαRI/anti-CD20 bispecific monoclonal antibody (BsAb (CD89-CD20)) that mediates recruitment of macrophages to tumour cells has been reported to enhance tumour cell killing [3], indicating that exploiting FcαRI-expressing cells as effector cells is a valid immuno-oncology strategy.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
macrophage (CL:0000235)
Comment:  FcαRI (CD89) is constitutively expressed on monocytes/macrophages.
References:  6
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
neutrophil (CL:0000775)
Comment:  FcαRI (CD89) is constitutively expressed on eosinophils, and neutrophils.
References:  6
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0042119 neutrophil activation IDA
GO:0043312 neutrophil degranulation TAS
GO:0071346 cellular response to interferon-gamma IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0019766 IgA receptor activity IDA
GO:0033031 positive regulation of neutrophil apoptotic process IDA
GO:0038093 Fc receptor signaling pathway IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0035457 cellular response to interferon-alpha IDA
GO:0071346 cellular response to interferon-gamma IDA
GO:0071354 cellular response to interleukin-6 IDA
GO:0071356 cellular response to tumor necrosis factor IDA
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0019766 IgA receptor activity IDA
GO:0038093 Fc receptor signaling pathway IDA
GO:0042119 neutrophil activation IDA
GO:0043312 neutrophil degranulation TAS

References

Show »

1. Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ et al.. (2018) FcαRI co-stimulation converts human intestinal CD103+dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nat Commun, 9 (1): 863. [PMID:29491406]

2. Kremer EJ, Kalatzis V, Baker E, Callen DF, Sutherland GR, Maliszewski CR. (1992) The gene for the human IgA Fc receptor maps to 19q13.4. Hum Genet, 89 (1): 107-8. [PMID:1577457]

3. Li B, Xu L, Pi C, Yin Y, Xie K, Tao F, Li R, Gu H, Fang J. (2017) CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy. Oncoimmunology, 7 (1): e1380142. [PMID:29296544]

4. Mantis NJ, Rol N, Corthésy B. (2011) Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol, 4 (6): 603-11. [PMID:21975936]

5. Mathias A, Pais B, Favre L, Benyacoub J, Corthésy B. (2014) Role of secretory IgA in the mucosal sensing of commensal bacteria. Gut Microbes, 5 (6): 688-95. [PMID:25536286]

6. Morton HC, van Egmond M, van de Winkel JG. (1996) Structure and function of human IgA Fc receptors (Fc alpha R). Crit Rev Immunol, 16 (4): 423-40. [PMID:8954257]

7. Pabst O. (2012) New concepts in the generation and functions of IgA. Nat Rev Immunol, 12 (12): 821-32. [PMID:23103985]

8. Stockmeyer B, Dechant M, van Egmond M, Tutt AL, Sundarapandiyan K, Graziano RF, Repp R, Kalden JR, Gramatzki M, Glennie MJ et al.. (2000) Triggering Fc alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy. J Immunol, 165 (10): 5954-61. [PMID:11067958]

How to cite this page

CD molecules: Fc fragment of IgA receptor. Last modified on 29/08/2018. Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2991.