tripartite motif containing 38 | 2.3.2.27 RING-type E3 ubiquitin transferase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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tripartite motif containing 38

  Target has curated data in GtoImmuPdb

Target id: 2984

Nomenclature: tripartite motif containing 38

Systematic Nomenclature: TRIM38

Family: 2.3.2.27 RING-type E3 ubiquitin transferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 465 6p22.2 TRIM38 tripartite motif containing 38
Mouse - 471 13 A3.1 Trim38 tripartite motif-containing 38
Rat - - 17p11 Trim38 tripartite motif containing 38
Previous and Unofficial Names
ring finger protein 15 | RNF15 | RORET | tripartite motif-containing 38
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.2.27
Description Reaction Reference
Transfer of ubiquitin to L-lysine residue of the acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Immunopharmacology Comments
TRIM38 catalyses the ubiquitination of Lys48 of the Toll-like receptor (TLR) adaptor protein TICAM1 (commonly referred to as TRIF) which mediates its proteosomal degradation. This action has been shown to inhibit TLR3-driven type I interferon signaling of the innate immune response [2]. The participation of TRIM38 in immune and inflammatory response regulation is reviewed by Hu and Shu (2017) [1].
Immuno Process Associations
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes
GO:0046598 positive regulation of viral entry into host cell IDA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0060333 interferon-gamma-mediated signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0060333 interferon-gamma-mediated signaling pathway TAS
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GO:0032648 regulation of interferon-beta production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0070936 protein K48-linked ubiquitination IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0050687 negative regulation of defense response to virus IEA
General Comments
TRIM38 is an E3 ubiquitin ligase. It is required for innate immune response initiation upon detection of viral RNA or DNA by dedicated sensors [1].

References

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1. Hu MM, Shu HB. (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell. Mol. Immunol., 14 (4): 331-338. [PMID:28194022]

2. Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T. (2012) TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation. PLoS ONE, 7 (10): e46825. [PMID:23056470]

How to cite this page

2.3.2.27 RING-type E3 ubiquitin transferase: tripartite motif containing 38. Last modified on 05/02/2018. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2984.