leukocyte associated immunoglobulin like receptor 1 (CD305) | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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leukocyte associated immunoglobulin like receptor 1 (CD305)

  Target has curated data in GtoImmuPdb

Target id: 2974

Nomenclature: leukocyte associated immunoglobulin like receptor 1 (CD305)

Abbreviated Name: LAIR1

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 287 19q13.42 LAIR1 leukocyte associated immunoglobulin like receptor 1
Mouse 1 263 7 A1; 7 2.31 cM Lair1 leukocyte-associated Ig-like receptor 1
Rat 1 263 1q21 Lair1 leukocyte-associated immunoglobulin-like receptor 1
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been found for the human and mouse genes. We provide the RefSeqs and gene/protein information for isoform 1 (Hs) and isoform a (Mm)..
Previous and Unofficial Names
Lair-1 | leukocyte-associated Ig-like receptor 1 | leukocyte-associated immunoglobulin-like receptor 1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
LAIR1 has been identified as a potential molecular receptor for Plasmodium falciparum-coded proteins that are expressed by infected host erythrocytes. Interaction of these parasite RIFIN proteins (encoded by rif genes) and inhibitory leucocyte receptors such as LAIR1 may mediate parasite-driven evasion of the host's immune system [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050776 regulation of immune response TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
General Comments
LAIR1 (CD305) is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells.

References

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1. Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S et al.. (2017) Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature, 552 (7683): 101-105. [PMID:29186116]

How to cite this page

CD molecules: leukocyte associated immunoglobulin like receptor 1 (CD305). Last modified on 06/12/2017. Accessed on 16/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2974.