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Fc fragment of IgE receptor Ig

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2934

Nomenclature: Fc fragment of IgE receptor Ig

Abbreviated Name: FCεR1γ

Family: Fc epsilon receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 86 1q23.3 FCER1G Fc epsilon receptor Ig
Mouse 1 86 1 79.23 cM Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide
Rat 1 86 13q24 Fcer1g Fc epsilon receptor Ig
Previous and Unofficial Names Click here for help
Fc receptor, IgE, high affinity I, gamma polypeptide | Fc receptor | Fc epsilon receptor Ig | high affinity I, receptor for Fc fragment of IgE | Ly-50
Database Links Click here for help
Alphafold P30273 (Hs), P20491 (Mm), P20411 (Rn)
Ensembl Gene ENSG00000158869 (Hs), ENSMUSG00000058715 (Mm), ENSRNOG00000024159 (Rn)
Entrez Gene 2207 (Hs), 14127 (Mm), 25441 (Rn)
Human Protein Atlas ENSG00000158869 (Hs)
KEGG Gene hsa:2207 (Hs), mmu:14127 (Mm), rno:25441 (Rn)
OMIM 147139 (Hs)
Pharos P30273 (Hs)
RefSeq Nucleotide NM_004106 (Hs), NM_010185 (Mm), NM_001131001 (Rn)
RefSeq Protein NP_004097 (Hs), NP_034315 (Mm), NP_001124473 (Rn)
UniProtKB P30273 (Hs), P20491 (Mm), P20411 (Rn)
Wikipedia FCER1G (Hs)
Immunopharmacology Comments
The FCER1G protein is a gamma subunit that is utilised as part of the high affinity IgE receptor (a key complex involved in mediating allergic reactions) and other Fc receptors.
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 5 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
GO:0031623 receptor internalization ISS
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
GO:0050766 positive regulation of phagocytosis IBA
click arrow to show/hide IEA associations
GO:0006911 phagocytosis, engulfment IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0016064 immunoglobulin mediated immune response IBA
click arrow to show/hide IEA associations
GO:0001798 positive regulation of type IIa hypersensitivity IEA
GO:0001805 positive regulation of type III hypersensitivity IEA
GO:0001812 positive regulation of type I hypersensitivity IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 8 GO processes
GO:0002283 neutrophil activation involved in immune response IBA
GO:0002292 T cell differentiation involved in immune response IBA
GO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
GO:0019767 IgE receptor activity IBA
GO:0038094 Fc-gamma receptor signaling pathway IBA
GO:0038095 Fc-epsilon receptor signaling pathway IMP
click arrow to show/hide IEA associations
GO:0043303 mast cell degranulation IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0030593 neutrophil chemotaxis IBA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0032753 positive regulation of interleukin-4 production ISS
GO:0038156 interleukin-3-mediated signaling pathway ISS
click arrow to show/hide IEA associations
GO:0032733 positive regulation of interleukin-10 production IEA
GO:0032755 positive regulation of interleukin-6 production IEA
GO:0032760 positive regulation of tumor necrosis factor production IEA
GO:0032765 positive regulation of mast cell cytokine production IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 11 GO processes
GO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
GO:0019767 IgE receptor activity IBA
GO:0038094 Fc-gamma receptor signaling pathway IBA
GO:0038095 Fc-epsilon receptor signaling pathway IMP
click arrow to show/hide IEA associations
GO:0001798 positive regulation of type IIa hypersensitivity IEA
GO:0001805 positive regulation of type III hypersensitivity IEA
GO:0001812 positive regulation of type I hypersensitivity IEA
GO:0032765 positive regulation of mast cell cytokine production IEA
GO:0033024 mast cell apoptotic process IEA
GO:0033026 negative regulation of mast cell apoptotic process IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0002292 T cell differentiation involved in immune response IBA
Immuno Process:  Inflammation
GO Annotations:  Associated to 12 GO processes
GO:0002283 neutrophil activation involved in immune response IBA
GO:0002292 T cell differentiation involved in immune response IBA
GO:0030593 neutrophil chemotaxis IBA
GO:0045087 innate immune response IBA
GO:0050766 positive regulation of phagocytosis IBA
click arrow to show/hide IEA associations
GO:0001798 positive regulation of type IIa hypersensitivity IEA
GO:0001805 positive regulation of type III hypersensitivity IEA
GO:0001812 positive regulation of type I hypersensitivity IEA
GO:0002554 serotonin secretion by platelet IEA
GO:0006911 phagocytosis, engulfment IEA
GO:0043303 mast cell degranulation IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 5 GO processes
GO:0002292 T cell differentiation involved in immune response IBA
GO:0016064 immunoglobulin mediated immune response IBA
click arrow to show/hide IEA associations
GO:0001798 positive regulation of type IIa hypersensitivity IEA
GO:0001805 positive regulation of type III hypersensitivity IEA
GO:0001812 positive regulation of type I hypersensitivity IEA

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ig. Last modified on 17/10/2018. Accessed on 21/06/2026. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2934.