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Fc fragment of IgE receptor Ig

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2934

Nomenclature: Fc fragment of IgE receptor Ig

Abbreviated Name: FCεR1γ

Family: Fc epsilon receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 86 1q23.3 FCER1G Fc epsilon receptor Ig
Mouse 1 86 1 79.23 cM Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide
Rat 1 86 13q24 Fcer1g Fc epsilon receptor Ig
Previous and Unofficial Names Click here for help
Fc receptor, IgE, high affinity I, gamma polypeptide | Fc receptor | Fc epsilon receptor Ig | high affinity I, receptor for Fc fragment of IgE | Ly-50
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
The FCER1G protein is a gamma subunit that is utilised as part of the high affinity IgE receptor (a key complex involved in mediating allergic reactions) and other Fc receptors.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0002283 neutrophil activation involved in immune response IBA
GO:0002292 T cell differentiation involved in immune response IBA
GO:0030593 neutrophil chemotaxis IBA
GO:0045087 innate immune response IBA
GO:0050766 positive regulation of phagocytosis IBA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 3 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
GO:0031623 receptor internalization ISS
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0002292 T cell differentiation involved in immune response IBA
GO:0016064 immunoglobulin mediated immune response IBA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0016064 immunoglobulin mediated immune response IBA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
GO:0019767 IgE receptor activity IBA
GO:0038094 Fc-gamma receptor signaling pathway IBA
GO:0038095 Fc-epsilon receptor signaling pathway IMP
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0002292 T cell differentiation involved in immune response IBA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0030593 neutrophil chemotaxis IBA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0002283 neutrophil activation involved in immune response IBA
GO:0002292 T cell differentiation involved in immune response IBA
GO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
GO:0019767 IgE receptor activity IBA
GO:0038094 Fc-gamma receptor signaling pathway IBA
GO:0038095 Fc-epsilon receptor signaling pathway IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0032753 positive regulation of interleukin-4 production ISS
GO:0038156 interleukin-3-mediated signaling pathway ISS

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ig. Last modified on 17/10/2018. Accessed on 30/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2934.