Top ▲

Fc fragment of IgE receptor Ia

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2933

Nomenclature: Fc fragment of IgE receptor Ia

Abbreviated Name: FCεR1α

Family: Fc epsilon receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 257 1q23.2 FCER1A Fc fragment of IgE receptor Ia
Mouse 1 250 1 80.33 cM Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Rat 1 245 13q24 Fcer1a Fc fragment of IgE receptor Ia
Previous and Unofficial Names Click here for help
Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IgE heavy chain Peptide Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 10.0 pKd
pKd 10.0 (Kd 1x10-10 M)
Immunopharmacology Comments
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   basophil (CL:0000767)
eosinophil (CL:0000771)
Immuno Cell Type:  Macrophages & monocytes
Comment:  Langerhans cells
Immuno Cell Type:  Mast cells
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 6 GO processes
GO:0001812 positive regulation of type I hypersensitivity IMP
GO:0019767 IgE receptor activity IDA
GO:0019768 high-affinity IgE receptor activity TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043306 positive regulation of mast cell degranulation IDA
GO:0050776 regulation of immune response IBA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0019767 IgE receptor activity IDA
GO:0019768 high-affinity IgE receptor activity TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043306 positive regulation of mast cell degranulation IDA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0001812 positive regulation of type I hypersensitivity IMP
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0001812 positive regulation of type I hypersensitivity IMP
GO:0043306 positive regulation of mast cell degranulation IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0001812 positive regulation of type I hypersensitivity IMP

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2933.