Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	257	1q23.2	FCER1A	Fc epsilon receptor Ia
Mouse	1	250	1 80.33 cM	Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide
Rat	1	245	13q24	Fcer1a	Fc epsilon receptor Ia

Previous and Unofficial Names

Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor

Database Links
Alphafold	P12319 (Hs), P20489 (Mm), P12371 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2248 (Hs)
Ensembl Gene	ENSG00000179639 (Hs), ENSMUSG00000005339 (Mm), ENSRNOG00000009177 (Rn)
Entrez Gene	2205 (Hs), 14125 (Mm), 25047 (Rn)
Human Protein Atlas	ENSG00000179639 (Hs)
KEGG Gene	hsa:2205 (Hs), mmu:14125 (Mm), rno:25047 (Rn)
OMIM	47140 (Hs)
Pharos	P12319 (Hs)
RefSeq Nucleotide	NM_002001 (Hs), NM_010184 (Mm), NM_012724 (Rn)
RefSeq Protein	NP_001992 (Hs), NP_034314 (Mm), NP_036856 (Rn)
UniProtKB	P12319 (Hs), P20489 (Mm), P12371 (Rn)
Wikipedia	FCER1A (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference IgE heavy chain Hs Binding 10.0 pKd ⤷ pKd 10.0 (Kd 1x10-10 M)

Immunopharmacology Comments

The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.

Cell Type Associations

Immuno Cell Type:  Granulocytes Cell Ontology Term:   basophil (CL:0000767) eosinophil (CL:0000771)

Immuno Cell Type:  Macrophages & monocytes Comment:  Langerhans cells

Immuno Cell Type:  Mast cells

Immuno Process Associations

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  B cell (activation)

Immuno Process:  Cytokine production & signalling

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)