Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	219	12p13.31	CLEC4E	C-type lectin domain family 4 member E
Mouse	1	214	6 58.35 cM	Clec4e	C-type lectin domain family 4, member e
Rat	1	215	4q42	Clec4e	C-type lectin domain family 4, member E

Previous and Unofficial Names

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 | CLECSF9 | Macrophage-inducible C-type lectin | C-type lectin domain family 4, member E | C-type lectin domain family 4, member e | C-type lectin domain family 4

Database Links
Alphafold	Q9ULY5 (Hs), Q9R0Q8 (Mm), Q67EQ1 (Rn)
CATH/Gene3D	3.10.100.10
ChEMBL Target	CHEMBL4105898 (Hs), CHEMBL4105754 (Mm)
Ensembl Gene	ENSG00000166523 (Hs), ENSMUSG00000030142 (Mm), ENSRNOG00000061394 (Rn)
Entrez Gene	26253 (Hs), 56619 (Mm), 450223 (Rn)
Human Protein Atlas	ENSG00000166523 (Hs)
KEGG Gene	hsa:26253 (Hs), mmu:56619 (Mm), rno:450223 (Rn)
OMIM	609962 (Hs)
Pharos	Q9ULY5 (Hs)
RefSeq Nucleotide	NM_014358 (Hs), NM_019948 (Mm), NM_001005897 (Rn)
RefSeq Protein	NP_055173 (Hs), NP_064332 (Mm), NP_001005897 (Rn)
UniProtKB	Q9ULY5 (Hs), Q9R0Q8 (Mm), Q67EQ1 (Rn)
Wikipedia	CLEC4E (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference GlcC14C18 Hs Agonist ~10.0 pEC50 2 ⤷ pEC50 ~10.0 (EC50 ~1x10-10 M) [2] Description: Measuring activation of an NF-κB reporter in HEK293 cells expressing human mincle.

Immunopharmacology Comments

Mincle is an FcRγ-associated membrane receptor involved in initiating the innate immune response upon recognition of endogenous and exogenous ligands including Sin3A-associated protein (SAP130), α-mannan on fungal cell walls and mycobacterial cord factor (trehalose-6,6′-dimycolate (TDM)) [1]. Mincle signals to NF-κB via the Syk-Card9-Bcl10-Malt1 pathway and induces a robust Th1 and Th17 response. Mincle is being targeted pharmacologically in an attempt to produce novel vaccine adjuvants that enhance cell-mediated immune responses [2]- in this case based on the immunogenicity of TDM. Mincle's role in human B cell responses was investigated in [3].

Cell Type Associations

Immuno Cell Type:  B cells Cell Ontology Term:   B cell (CL:0000236) References:  3

Immuno Cell Type:  Granulocytes Cell Ontology Term:   neutrophil (CL:0000775) References:  3

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451)

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235)

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

General Comments
Mincle is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).