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Target has curated data in GtoImmuPdb
Target id: 2928
Nomenclature: C-type lectin domain family 6 member A
Abbreviated Name: Dectin-2
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 209 | 12p13.31 | CLEC6A | C-type lectin domain containing 6A | |
Mouse | 1 | 209 | 6 58.3 cM | Clec4n | C-type lectin domain family 4, member n | |
Gene and Protein Information Comments | ||||||
A shorter transcript and protein isoform of human the CLEC6A gene have been reported [1]. Two alternative transcripts and protein isoforms arising from the mouse gene have been identified. A rat homolog of human CLEC6A has not been identified. |
Database Links | |
Alphafold | Q6EIG7 (Hs), Q9JKF4 (Mm) |
CATH/Gene3D | 3.10.100.10 |
ChEMBL Target | CHEMBL2176856 (Hs) |
Ensembl Gene | ENSG00000205846 (Hs), ENSMUSG00000023349 (Mm) |
Entrez Gene | 93978 (Hs), 56620 (Mm) |
Human Protein Atlas | ENSG00000205846 (Hs) |
KEGG Gene | hsa:93978 (Hs), mmu:56620 (Mm) |
OMIM | 613579 (Hs) |
Pharos | Q6EIG7 (Hs) |
RefSeq Nucleotide | NM_001007033 (Hs), NM_020001 (Mm) |
RefSeq Protein | NP_001007034 (Hs), NP_064385 (Mm) |
UniProtKB | Q6EIG7 (Hs), Q9JKF4 (Mm) |
Wikipedia | CLEC6A (Hs) |
Immunopharmacology Comments |
Dectin-2 is involved in initiating the innate immune response upon recognition of high mannose structures on fungal cell walls. It associates with the ITAM-containing FcRβ adaptor and signals through the Syk, PKCδ, and CARD9-Bcl10-MALT1 pathways to promote cytokine production in response to fungal infection. |
Immuno Process Associations | ||
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General Comments |
Dectin-2 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). |
C-type lectin-like receptors (CLRs): C-type lectin domain family 6 member A. Last modified on 20/03/2017. Accessed on 14/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2928.