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myeloid cell nuclear differentiation antigen

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2926

Nomenclature: myeloid cell nuclear differentiation antigen

Abbreviated Name: MNDA

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 407 1q23.1 MNDA myeloid cell nuclear differentiation antigen
Rat - 438 13q24 Mnda myeloid cell nuclear differentiation antigen
Gene and Protein Information Comments
There are no mouse homologs of human MNDA.
Previous and Unofficial Names Click here for help
PYHIN3
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
The HIN (ligand binding) domain of MDNA binds double-stranded DNA with a Kd of 3.15 μM [2].
Immunopharmacology Comments
MNDA can be detected exclusively in nuclei of hematopoietic cells of the monocyte lineage. Expression is induced by interferon α [1]. The HIN domain of MNDA binds double-stranded DNA [2], and produces an innate resonse against pathogens. MNDA may be able to detect some viruses not recognized by AIM2.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  Cytokine production & signalling
General Comments
MNDA is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995).

References

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1. Briggs JA, Burrus GR, Stickney BD, Briggs RC. (1992) Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. J Cell Biochem, 49 (1): 82-92. [PMID:1644857]

2. Li H, Wang ZX, Wu JW. (2014) Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). Biotechnol Lett, 36 (5): 899-905. [PMID:24557068]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): myeloid cell nuclear differentiation antigen. Last modified on 03/03/2017. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2926.