Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	254	2p23.1	SRD5A2	steroid 5 alpha-reductase 2
Mouse	4	254	17 E2	Srd5a2	steroid 5 alpha-reductase 2
Rat	4	254	6q14	Srd5a2	steroid 5 alpha-reductase 2

Previous and Unofficial Names

3-oxo-5-alpha-steroid 4-dehydrogenase 2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Database Links
Alphafold	P31213 (Hs), Q99N99 (Mm), P31214 (Rn)
BRENDA	1.3.99.5
ChEMBL Target	CHEMBL1856 (Hs), CHEMBL5099 (Rn)
DrugBank Target	P31213 (Hs)
Ensembl Gene	ENSG00000277893 (Hs), ENSMUSG00000038541 (Mm), ENSRNOG00000027042 (Rn)
Entrez Gene	6716 (Hs), 94224 (Mm), 64677 (Rn)
Human Protein Atlas	ENSG00000277893 (Hs)
KEGG Enzyme	1.3.99.5
KEGG Gene	hsa:6716 (Hs), mmu:94224 (Mm), rno:64677 (Rn)
OMIM	607306 (Hs)
Orphanet	ORPHA119860 (Hs)
Pharos	P31213 (Hs)
RefSeq Nucleotide	NM_000348 (Hs), NM_053188 (Mm), NM_022711 (Rn)
RefSeq Protein	NP_000339 (Hs), NP_444418 (Mm), NP_073202 (Rn)
UniProtKB	P31213 (Hs), Q99N99 (Mm), P31214 (Rn)
Wikipedia	SRD5A2 (Hs)

Enzyme Reaction
EC Number: 1.3.99.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference finasteride Hs Inhibition 7.8 pIC50 1 ⤷ pIC50 7.8 (IC50 1.46x10-8 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency Synonyms: Pseudovaginal perineoscrotal hypospadias; PPSH [OMIM: 264600] OMIM: 264600 Orphanet: ORPHA753
Disease:  Familial prostate cancer Synonyms: Prostate cancer [OMIM: 176807] [Disease Ontology: DOID:10283] Disease Ontology: DOID:10283 OMIM: 176807 Orphanet: ORPHA1331