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proprotein convertase subtilisin/kexin type 2

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Target not currently curated in GtoImmuPdb

Target id: 2383

Nomenclature: proprotein convertase subtilisin/kexin type 2

Family: S8: Subtilisin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 638 20p12.1 PCSK2 proprotein convertase subtilisin/kexin type 2
Mouse - 637 2 70.89 cM Pcsk2 proprotein convertase subtilisin/kexin type 2
Rat - 637 3q41 Pcsk2 proprotein convertase subtilisin/kexin type 2
Previous and Unofficial Names Click here for help
NEC 2 | PC2 | Phpp-2 | prohormone convertase 2 | proprotein convertase 2 | SPC2 | neuroendocrine convertase 2
Database Links Click here for help
Specialist databases
MEROPS S08.073 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.94

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide 18 [PMID: 24350995] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.4x10-10 M) [1]

References

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1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem, 57 (1): 98-109. [PMID:24350995]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 2. Last modified on 27/07/2015. Accessed on 16/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2383.