Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	753	5q15	PCSK1	proprotein convertase subtilisin/kexin type 1
Mouse	-	753	13 40.63 cM	Pcsk1	proprotein convertase subtilisin/kexin type 1
Rat	-	752	2q23	Pcsk1	proprotein convertase subtilisin/kexin type 1

Previous and Unofficial Names

neuroendocrine convertase 1 | prohormone convertase 1 | BDP | NEC1 | PC1 | PC3 | Phpp-1 | prohormone convertase 3 | propeptide-processing protease | SPC3

Database Links
Specialist databases
MEROPS	S08.072 (Hs)
Other databases
Alphafold	P29120 (Hs), P63239 (Mm), P28840 (Rn)
BRENDA	3.4.21.93
CATH/Gene3D	2.60.120.260, 3.40.50.200
ChEMBL Target	CHEMBL3182 (Hs)
Ensembl Gene	ENSG00000175426 (Hs), ENSMUSG00000021587 (Mm), ENSRNOG00000011107 (Rn)
Entrez Gene	5122 (Hs), 18548 (Mm), 25204 (Rn)
Human Protein Atlas	ENSG00000175426 (Hs)
KEGG Enzyme	3.4.21.93
KEGG Gene	hsa:5122 (Hs), mmu:18548 (Mm), rno:25204 (Rn)
OMIM	162150 (Hs)
Orphanet	ORPHA124131 (Hs)
Pharos	P29120 (Hs)
RefSeq Nucleotide	NM_000439 (Hs), NM_001177875 (Hs), NM_013628 (Mm), NM_017091 (Rn)
RefSeq Protein	NP_000430 (Hs), NP_001171346 (Hs), NP_038656 (Mm), NP_058787 (Rn)
UniProtKB	P29120 (Hs), P63239 (Mm), P28840 (Rn)
Wikipedia	PCSK1 (Hs)

Enzyme Reaction
EC Number: 3.4.21.93

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Hs Inhibition 9.1 pKi 1 ⤷ pKi 9.1 (Ki 7.5x10-10 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Obesity due to prohormone convertase I deficiency OMIM: 600955, 612362 Orphanet: ORPHA71528