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Target has curated data in GtoImmuPdb
Target id: 2317
Nomenclature: Interleukin-6 receptor, β subunit
Abbreviated Name: IL6ST
Systematic Nomenclature: interleukin 6 signal transducer
Family: IL-6 receptor family
Quaternary Structure: Complexes |
Interleukin-6 receptor |
Interleukin-11 receptor |
Ciliary neutrophic factor receptor |
Leukemia inhibitory factor receptor |
Oncostatin-M receptor |
Interleukin-27 receptor |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 918 | 5q11.2 | IL6ST | interleukin 6 cytokine family signal transducer | |
Mouse | 1 | 917 | 13 63.73 cM | Il6st | interleukin 6 signal transducer | |
Rat | 1 | 918 | 2q14-q16 | Il6st | interleukin 6 cytokine family signal transducer |
Database Links | |
Alphafold | P40189 (Hs), Q00560 (Mm), P40190 (Rn) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL3124734 (Hs) |
Ensembl Gene | ENSG00000134352 (Hs), ENSMUSG00000021756 (Mm), ENSRNOG00000013963 (Rn) |
Human Protein Atlas | ENSG00000134352 (Hs) |
OMIM | 600694 (Hs) |
Pharos | P40189 (Hs) |
UniProtKB | P40189 (Hs), Q00560 (Mm), P40190 (Rn) |
Wikipedia | IL6ST (Hs) |
Selected 3D Structures | |||||||||||
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Immunopharmacology Comments |
This is the common signal transducing subunit shared by members of the IL-6 family of cytokine receptors [2]. IL-6/IL-6R regulated signalling pathways represent a druggable target for the therapy of chronic inflammatory and autoimmune diseases, and cancer [3]. IL6ST (gp130) is being investigated as therapeutic target for the treatment of autoimmune diseases [3-4]. For example i-Mab Biopharma have a gp130 targeting Fc fusion protein (olamkicept; TJ301) in early stage clinical trial in patients with active ulcerative colitis (Ph2 NCT03235752). |
1. Bravo J, Staunton D, Heath JK, Jones EY. (1998) Crystal structure of a cytokine-binding region of gp130. EMBO J, 17 (6): 1665-74. [PMID:9501088]
2. Rose-John S. (2018) Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol, 10 (2). [PMID:28620096]
3. Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets, 11 (5): 613-24. [PMID:17465721]
4. Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S et al.. (2014) Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs, 6 (3): 774-82. [PMID:24670876]
IL-6 receptor family: Interleukin-6 receptor, β subunit. Last modified on 15/04/2019. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2317.