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serine/threonine kinase 31

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Target not currently curated in GtoImmuPdb

Target id: 2220

Nomenclature: serine/threonine kinase 31

Abbreviated Name: STK31

Family: Other-unique family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1019 7p15.3 STK31 serine/threonine kinase 31
Mouse - 1018 6 B2.3 Stk31 serine threonine kinase 31
Rat - 1018 4q24 Stk31 serine threonine kinase 31
Previous and Unofficial Names Click here for help
SgK396 | TDRD8
Database Links Click here for help
Alphafold Q9BXU1 (Hs), Q99MW1 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL6151 (Hs)
Ensembl Gene ENSG00000196335 (Hs), ENSMUSG00000023403 (Mm), ENSRNOG00000057554 (Rn)
Entrez Gene 56164 (Hs), 77485 (Mm), 500120 (Rn)
Human Protein Atlas ENSG00000196335 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:56164 (Hs), mmu:77485 (Mm), rno:500120 (Rn)
OMIM 605790 (Hs)
Pharos Q9BXU1 (Hs)
RefSeq Nucleotide NM_031414 (Hs), NM_029916 (Mm), NM_001191971 (Rn)
RefSeq Protein NP_113602 (Hs), NP_084192 (Mm), NP_001178900 (Rn)
UniProtKB Q9BXU1 (Hs), Q99MW1 (Mm)
Wikipedia STK31 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 25 [PMID: 17935989] Small molecule or natural product Click here for species-specific activity table Hs Inhibition <5.8 pKi 1
⤷ pKi <5.8 (Ki >1.422x10-6 M) [1]

References

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1. Tao ZF, Chen Z, Bui MH, Kovar P, Johnson E, Bouska J, Zhang H, Rosenberg S, Sowin T, Lin NH. (2007) Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. Bioorg Med Chem Lett, 17 (23): 6593-601. [PMID:17935989]

How to cite this page

Other-unique family: serine/threonine kinase 31. Last modified on 15/10/2015. Accessed on 25/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2220.