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Interleukin-22α1/10β heteromer

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1903

Nomenclature: Interleukin-22α1/10β heteromer

Family: IL-10 receptor family

Quaternary Structure: Subunits
Interleukin 10 receptor, β subunit (Ligand-binding subunit)
Interleukin 22 receptor, α1 subunit (Ligand-binding subunit)
Natural/Endogenous Ligands Click here for help
IL-22 {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-22 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 11.5 pEC50 1
pEC50 11.5 (EC50 3.5x10-12 M) [1]
Description: EC50 for rhIL-22-induced STAT3 activation in HEK293 cells that overexpress the human IL-22 heterodimeric receptor
efmarodocokin alfa Peptide Hs Agonist 9.9 pEC50 1
pEC50 9.9 (EC50 1.2x10-10 M) [1]
Description: EC50 for fusion protein-induced STAT3 activation in HEK293 cells that overexpress the human IL-22 heterodimeric receptor
Immunopharmacology Comments
This is a heterodimeric receptor containing interleukin 10 receptor, β subunit (IL10RB) and interleukin 22 receptor, α1 subunit (IL22RA1). It is a receptor for interleukin 22.

References

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1. Stefanich EG, Rae J, Sukumaran S, Lutman J, Lekkerkerker A, Ouyang W, Wang X, Lee D, Danilenko DM, Diehl L et al.. (2018) Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases. Biochem Pharmacol, 152: 224-235. [PMID:29608910]

How to cite this page

IL-10 receptor family: Interleukin-22α1/10β heteromer. Last modified on 05/10/2022. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1903.