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Quaternary Structure: Subunits |
Interleukin 10 receptor, β subunit (Ligand-binding subunit) |
Interleukin 22 receptor, α1 subunit (Ligand-binding subunit) |
Natural/Endogenous Ligands |
IL-22 {Sp: Human} |
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Immunopharmacology Comments |
This is a heterodimeric receptor containing interleukin 10 receptor, β subunit (IL10RB) and interleukin 22 receptor, α1 subunit (IL22RA1). It is a receptor for interleukin 22. |
1. Stefanich EG, Rae J, Sukumaran S, Lutman J, Lekkerkerker A, Ouyang W, Wang X, Lee D, Danilenko DM, Diehl L et al.. (2018) Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases. Biochem Pharmacol, 152: 224-235. [PMID:29608910]
IL-10 receptor family: Interleukin-22α1/10β heteromer. Last modified on 05/10/2022. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1903.