death receptor 6 | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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death receptor 6

  Target has curated data in GtoImmuPdb

Target id: 1893

Nomenclature: death receptor 6

Abbreviated Name: DR6

Systematic Nomenclature: TNFRSF21

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 655 06p12.3 TNFRSF21 TNF receptor superfamily member 21
Mouse 1 655 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21
Rat - - Tnfrsf21 TNF receptor superfamily member 21
Previous and Unofficial Names
tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRADD
Immunopharmacology Comments
Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0002250 adaptive immune response ISS
GO:0042130 negative regulation of T cell proliferation ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0001783 B cell apoptotic process ISS
GO:0002250 adaptive immune response ISS
GO:0030889 negative regulation of B cell proliferation ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0030889 negative regulation of B cell proliferation ISS
GO:0042130 negative regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0071356 cellular response to tumor necrosis factor IDA
GO:2000663 negative regulation of interleukin-5 secretion ISS
GO:2000666 negative regulation of interleukin-13 secretion ISS
GO:2001180 negative regulation of interleukin-10 secretion ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0042130 negative regulation of T cell proliferation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0030889 negative regulation of B cell proliferation ISS
GO:0042130 negative regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway ISS

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: death receptor 6. Last modified on 22/03/2017. Accessed on 20/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1893.