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death receptor 6

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1893

Nomenclature: death receptor 6

Abbreviated Name: DR6

Systematic Nomenclature: TNFRSF21

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 655 6p12.3 TNFRSF21 TNF receptor superfamily member 21
Mouse 1 655 17 B3 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21
Rat - - Tnfrsf21 TNF receptor superfamily member 21
Previous and Unofficial Names Click here for help
tumor necrosis factor receptor superfamily, member 21 | CD358 | tumor necrosis factor receptor superfamily
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRADD
Immunopharmacology Comments
Expressed predominantly in the thymus, spleen and white blood cells. May play a role in T helper cell activation, inflammation and immune regulation. Signals via the TRADD adaptor protein to the NF-κB and MAPK8/JNK pathways.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0002250 adaptive immune response ISS
GO:0042130 negative regulation of T cell proliferation ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0001783 B cell apoptotic process ISS
GO:0002250 adaptive immune response ISS
GO:0030889 negative regulation of B cell proliferation ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0030889 negative regulation of B cell proliferation ISS
GO:0042130 negative regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0032693 negative regulation of interleukin-10 production ISS
GO:0032696 negative regulation of interleukin-13 production ISS
GO:0032714 negative regulation of interleukin-5 production ISS
GO:0071356 cellular response to tumor necrosis factor IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0042130 negative regulation of T cell proliferation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0030889 negative regulation of B cell proliferation ISS
GO:0042130 negative regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway ISS

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